Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro).
Body weight reduction in rats by oral treatment with zinc plus cyclo-(His-Pro).
复制标题
通过口服锌加环-(His-Pro) 治疗可减轻大鼠体重。
DOI：
10.1111/j.1476-5381.2009.00201.x
复制
发表时间：
2009
影响因子：
7.3
通讯作者：
Cornford,EM
中科院分区：
文献类型：
--
作者：
Song,MK;Rosenthal,MJ;Song,AM;Uyemura,K;Yang,H;Ament,ME;Yamaguchi,DT;Cornford,EM
背景和目的：我们之前的研究表明，锌加cyclo‐（His‐Pro） （CHP）治疗显著刺激胰岛素降解酶的合成，降低血浆胰岛素和血糖水平，同时改善遗传性2型糖尿病Goto‐Kakizaki （G‐K）大鼠和老年肥胖Sprague‐Dawley （S‐D）大鼠的口服葡萄糖耐量。因此，我们假设锌加CHP （ZC）治疗也可能改善这些大鼠的体重控制。因此，我们确定了ZC治疗对遗传性糖尿病、成熟G - K大鼠和非糖尿病、肥胖S - D大鼠体重的影响。实验方法：将1.5 ~ 10月龄G‐K大鼠和6 ~ 18月龄非糖尿病超重或肥胖S‐D大鼠分别给予0 ~ 6 mg CHP加0 ~ 10 mg锌·L−1饮用水治疗2 ~ 4周，观察体重、血清瘦素和脂联素水平、食物和水摄入量的变化。关键结果：在成熟的G‐K大鼠和老年超重或肥胖的S‐D大鼠中，CHP（联合锌）降低体重和血浆瘦素水平以及增加血浆脂联素水平的最佳剂量接近0.1 mg·kg−1·day−1。ZC处理后的老年S - D大鼠和成熟G - K大鼠的食物和水摄入量均显著减少，但在年轻S - D和G - K大鼠中没有。结论和意义：ZC治疗改善了体重控制，可能是超重和肥胖的治疗方法。
Background and purpose:We have previously shown that treatment with zinc plus cyclo‐(His‐Pro) (CHP) significantly stimulated synthesis of the insulin degrading enzyme and lowered plasma insulin and blood glucose levels, alongside improving oral glucose tolerance in genetically type 2 diabetic Goto‐Kakizaki (G‐K) rats and in aged obese Sprague‐Dawley (S‐D) rats. Thus, we postulated that zinc plus CHP (ZC) treatment might also improve body weight control in these rats. We therefore determined the effects of ZC treatment on body weights in both genetically diabetic, mature G‐K rats and non‐diabetic, obese S‐D rats.Experimental approach:G‐K rats aged 1.5–10 months and non‐diabetic overweight or obese S‐D rats aged 6–18 months were treated with 0–6 mg CHP plus 0–10 mg zinc·L−1drinking water for 2–4 weeks, and changes in weight, serum leptin and adiponectin levels, food and water intakes were measured.Key results:The optimal dose of CHP (in combination with zinc) to reduce weight and plasma leptin levels and to increase plasma adiponectin levels was close to 0.1 mg·kg−1·day−1, in either mature G‐K rats and aged overweight or obese S‐D rats. Food and water intake significantly decreased in ZC treated rats in both aged S‐D rats and mature G‐K rats, but not in young S‐D and G‐K rats.Conclusions and implications:ZC treatment improved weight control and may be a possible treatment for overweight and obesity.