Depressive symptoms and migraine comorbidity among pregnant Peruvian women
Depressive symptoms and migraine comorbidity among pregnant Peruvian women
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DOI：
10.1016/j.jad.2009.07.014
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发表时间：
2010-04-01
影响因子：
6.6
通讯作者：
Williams, Michelle A.
中科院分区：
文献类型：
--
作者：
Cripe, Swee May;Sanchez, Sixto;Williams, Michelle A.
背景：众所周知，偏头痛和抑郁症是未怀孕的女性和男性的共同疾病。然而，尚未对孕妇，特别是发展中国家妇女的偏头痛和抑郁症共病进行评估。因此，我们评估了一大批秘鲁孕妇中偏头痛与抑郁症状的关系。方法：在秘鲁利马的国家母婴研究所分娩的2293名单胎婴儿的产妇在产后住院期间接受了访谈。女性被问及与她们的生活和怀孕经历有关的头痛和偏头痛。对这些问题的回答使人们能够根据国际头痛协会的诊断标准将偏头痛分为“可能的”和“严重的”偏头痛。抑郁症状使用九项患者健康问卷抑郁子集进行评估。用Logistic回归方法估计调整后的优势比(AORS)和95%的可信区间(CI)。结果：大约32%的女性报告有偏头痛病史，而41%的女性报告在怀孕期间经历了中度到重度的抑郁症状。与无偏头痛病史的女性相比，重度偏头痛患者的中度、中度和重度抑郁症状的相对危险度分别为2.12(95%可信区间1.54~2.93)、1.85(95%可信区间1.16~2.96)和2.23(95%可信区间1.08~4.62)。如果我们的发现得到证实，有偏头痛病史的孕妇可能会受益于提高对抑郁症状的筛查和治疗的警惕。(C)2009爱思唯尔B.V.保留所有权利。
Background: Migraine and depression are known to he comorbid conditions in non-pregnant women and men. However, the migraine-depression comorbidity among pregnant women, particularly women in developing countries has not been evaluated. Therefore, we evaluated the migraine-depressive symptom relationship in a large cohort of pregnant Peruvian women.Methods: Women who delivered singleton infants (n = 2293) at the Instituto Nacional Materno Perinatal, Lima, Peru were interviewed during the postpartum hospital stay. Women were asked questions related to their lifetime and pregnancy experiences with headaches and migraines. Responses to these questions enabled the classification of "probable" and "strict" migraines according to the International Headache Society diagnostic criteria. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire Depression Subset. Logistic regression procedures were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs).Results: Approximately 32% of the women reported a history of migraine, while 41% reported experiencing moderate to severe depressive symptoms during pregnancy. Compared with women without a history of migraine, women with strict migraine had AORs of 2.12 (95% CI 1.54-2.93), 1.85 (95% CI 1.16-2.96) and 2.23 (95% CI 1.08-4.62) for moderate, moderately severe and severe depressive symptoms, respectively.Conclusion: This is the first report of a cross-sectional association between migraine and depressive symptoms in pregnant women. If our findings are confirmed, pregnant women with a history of migraine may benefit from increased vigilance for screening and treating depressive symptoms. (C) 2009 Elsevier B.V. All rights reserved.