Manufacturing and characterization of plates for fracture fixation of bone with biocomposites of poly (lactic acid-co-glycolic acid) (PLGA) with calcium phosphates bioceramics
Manufacturing and characterization of plates for fracture fixation of bone with biocomposites of poly (lactic acid-co-glycolic acid) (PLGA) with calcium phosphates bioceramics
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DOI：
10.1016/j.msec.2019.05.013
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发表时间：
2019-10-01
影响因子：
7.9
通讯作者：
Fredel, March Celso
中科院分区：
文献类型：
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作者：
Balestreri Knopf dos Santos, Thaiane Maria;Merlini, Claudia;Fredel, March Celso
商业上，有几种由PLA制成的用于骨折固定的接骨板和螺钉，然而，其降解时间长且缺乏与骨结构的整合，这使得人们对使用具有更快降解的聚合物（例如PLGA）并与生物陶瓷一起进行研究以提高骨再生中的生物活性产生了兴趣。基于此，在本研究中，骨折固定板由PLGA聚合物基质和5和10%wt.的生物陶瓷进行显微注射。所用的生物陶瓷包括纳米结构羟基磷灰石（n-HA）、β-磷酸三钙（β-TCP）和镁离子取代的磷酸钙（Mg-Ca/P）和锶离子取代的磷酸钙（Sr-Ca/P）。生物陶瓷的引入改性了聚合物的热性能和力学性能。TGA分析表明，插入的陶瓷质量相对于预期值（5%和10%wt.）在所有的生物复合材料中。一般来说，几乎所有生物复合材料的DMA获得的Tg值均略有增加。除了5% n-HA外，几乎所有嵌入陶瓷组的生物复合材料的储能模量（E '）都较高。在弯曲试验中，生物复合材料的断裂载荷的平均值得到了很大的分散，呈现出较低的值，相对于纯PLGA。在处理具有Mg-Ca/P和Sr-Ca/P的生物复合材料时存在困难，这是可归因于材料混合过程中缺乏均匀性的因素。结果表明，在PLGA板的热性能和机械性能与生物陶瓷插入的修改，并提供改进的理解与PLGA和生物陶瓷制造的复合材料。
Commercially, there are several plates and screws for bone fracture fixation made with PLA, however, its long degradation time and lack of integration with bone structure, provides interest in research using polymers with faster degradation, such as PLGA, and together with bioceramics, in order to improve bioactivity in bone regeneration. Based on this, in this study, bone fracture fixation plates composed of PLGA polymer matrix and combinations of 5 and 10%wt. of bioceramics were processed by microinjection. The bioceramics used comprehend nanostructured hydroxyapatite (n-HA), beta-tricalcium phosphate (beta-TCP) and calcium phosphate with ion substitution of magnesium (Mg-Ca/P) and strontium (Sr-Ca/P). The introduction of bioceramics modified thermal and mechanical properties of the polymer. The TGA analysis showed that there was a variation on the ceramic's mass inserted in relation to the expected values (5% and 10%wt.) in all groups of biocomposites. In general, Tg values obtained by DMA were slightly increased in almost all the biocomposites. The storage modulus (E') of biocomposites was higher for almost all groups of inserted ceramics, with exception of 5%n-HA. In the flexural tests, the biocomposites obtained a great dispersion in average values of fracture loading, presented lower values in relation to pure PLGA. There were difficulties in the processing of biocomposites with Mg-Ca/P and Sr-Ca/P, a factor that can be attributed to lack of homogeneity in the material mixing process. The results suggest modifications in thermal and mechanical properties of the PLGA plates with the bioceramics insertion and provide improvement understanding about of manufactured composites with PLGA and bioceramics.