Repetitive transcranial magnetic stimulation of human area MT/V5 disrupts perception and storage of the motion aftereffect
Repetitive transcranial magnetic stimulation of human area MT/V5 disrupts perception and storage of the motion aftereffect
复制标题
DOI：
10.1016/s0028-3932(02)00112-4
复制
发表时间：
2002-12
期刊：
影响因子：
2.6
通讯作者：
H. Théoret;Masahito Kobayashi;G. Ganis;P. D. Capua;Á. Pascual-Leone
中科院分区：
文献类型：
--
作者：
H. Théoret;Masahito Kobayashi;G. Ganis;P. D. Capua;Á. Pascual-Leone
在适应运动刺激之后，引入静止模式会产生运动的错觉。这种现象，被称为运动后效（MAE），可以通过在适应和测试刺激之间放置空白存储间隔来延迟。人类运动选择区MT/V5被认为可能是MAES的神经起源。为了研究MT/V5在感知和存储MAES中的作用，我们在10秒的存储间隔期间对该区域进行重复经颅磁刺激（rTMS），同时受试者感知虚幻运动。我们的研究结果表明，rTMS破坏感知的MAE时，它是在存储期间的早期部分，当它被应用在感知MAE本身。刺激对应于V1或Cz的对照区域不影响MAE。此外，磁刺激背外侧前额叶和后顶叶皮层没有破坏MAE的看法。这些数据提供了实验支持的概念，即MT/V5 subserves感知和存储的运动后效。
Following adaptation to a moving stimulus, the introduction of a stationary pattern creates the illusion of motion. This phenomenon, known as the motion aftereffect (MAE), can be delayed by placing a blank storage interval between the adapting and test stimuli. Human motion selective area MT/V5 has been proposed as the likely neural origin of MAEs. To examine the role of MT/V5 in perceiving and storing MAEs, we applied repetitive transcranial magnetic stimulation (rTMS) to this area during a 10s storage interval and while subjects perceived illusory motion. Our results show that rTMS disrupts perception of the MAE when it is delivered in the early parts of the storage period and when it is applied during the perceptual MAE itself. Stimulation of control regions corresponding to V1 or Cz did not affect the MAE. In addition, magnetic stimulation of dorsolateral prefrontal and posterior parietal cortices did not disrupt MAE perception. These data provide experimental support for the notion that MT/V5 subserves perception and storage of the motion aftereffect.