Human medial frontal cortex mediates unconscious inhibition of voluntary action.
Human medial frontal cortex mediates unconscious inhibition of voluntary action.
复制标题
DOI：
10.1016/j.neuron.2007.05.016
复制
发表时间：
2007-06-07
期刊：
影响因子：
16.2
通讯作者：
Husain, Masud
中科院分区：
文献类型：
--
作者：
Sumner, Petroc;Nachev, Parashkev;Morris, Peter;Peters, Andrew M.;Jackson, Stephen R.;Kennard, Christopher;Husain, Masud
Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain controversial. Here, we study two extremely rare patients with microlesions of the SEF and SMA to demonstrate that these areas are critically involved in unconscious and involuntary motor control. We employed masked-prime stimuli that evoked automatic inhibition in healthy people and control patients with lateral premotor or pre-SMA damage. In contrast, our SEF/SMA patients showed a complete reversal of the normal inhibitory effect—ocular or manual—corresponding to the functional subregion lesioned. These findings imply that the SEF and SMA mediate automatic effector-specific suppression of motor plans. This automatic mechanism may contribute to the participation of these areas in the voluntary control of action.
登录
查看更多内容
尾状反应的抑制是由尾状和丘脑介导的：功能性MRI和亨廷顿氏病的证据。
DOI：
10.1093/brain/awg067
发表时间：
2003-03
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Aron AR;Schlaghecken F;Fletcher PC;Bullmore ET;Eimer M;Barker R;Sahakian BJ;Robbins TW
通讯作者：
Robbins TW
影响因子：
2.6
作者：
Grèzes, J;Decety, J
通讯作者：
Decety, J
影响因子：
1.7
作者：
Chainay, H;Krainik, A;Lehéricy, S
通讯作者：
Lehéricy, S
影响因子：
2.5
作者：
CHEN, LL;WISE, SP
通讯作者：
WISE, SP
影响因子：
8.2
作者：
Leuthold, H;Kopp, B
通讯作者：
Kopp, B