Increased frontoparietal integration after stroke and cognitive recovery.
Increased frontoparietal integration after stroke and cognitive recovery.
复制标题
中风后额顶叶整合增强和认知恢复。
DOI：
10.1002/ana.21866
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发表时间：
2010
影响因子：
11.2
通讯作者：
Wise,RichardJS
中科院分区：
文献类型：
--
作者：
Sharp,DavidJ;Turkheimer,FedericoE;Bose,SubrataK;Scott,SophieK;Wise,RichardJS
脑损伤后患者自发恢复认知功能的神经机制尚不清楚。在这里，我们第一次证明，失语症患者，谁在很大程度上恢复了语言功能，表现出增加额顶叶整合。当正常受试者暴露于不利的听力条件下时，也观察到功能连接的类似变化。因此，对低效率语言处理的补偿与语言网络中对语言控制至关重要的部分之间的整合增加有关。这种变化反映了对言语理解的更大的自上而下的控制，并提供了一种机制，通过这种机制，中风后的语言障碍可以得到补偿。ANN NEUROL 2010
The neural mechanism by which patients spontaneously recover cognitive function after brain injury is not understood. Here we demonstrate for the first time that aphasic patients, who have largely recovered language function, show increased frontoparietal integration. A similar change in functional connectivity is also observed when normal subjects are exposed to adverse listening conditions. Thus, compensation for inefficient language processing is associated with increased integration between parts of the language network critical to language control. This change reflects greater top‐down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for. ANN NEUROL 2010