Characterization of mouse and human B7-H3 genes
Characterization of mouse and human B7-H3 genes
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DOI：
10.4049/jimmunol.168.12.6294
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发表时间：
2002-06-15
影响因子：
4.4
通讯作者：
Dong, C
中科院分区：
文献类型：
--
作者：
Sun, MY;Richards, S;Dong, C
T细胞活化和免疫功能是由B7超家族的共刺激分子调控的。人类B7-H3是该家族的新成员，已被证明可介导T细胞增殖和ifn - γ的产生。在这项工作中，我们描述了在多种组织中普遍表达的小鼠B7-H3同源物的鉴定。活化的CD4和CD8 T细胞表达一种假定的受体，可被可溶性小鼠B7-H3-Ig分子识别。虽然小鼠B7-H3基因被发现包含一个拷贝，但我们发现了人类B7-H3基因的一个新的同工异构体（以下称为B7-H3b），它具有四个由基因复制和差异剪接产生的igg样结构域。B7-H3b是几种组织中表达的主要亚型。这一结构信息表明B7-H3基因在哺乳动物物种中存在遗传变异。
T cell activation and immune function are regulated by costimulatory molecules of the B7 superfamily. Human B7-H3 is a recent addition to this family and has been shown to mediate T cell proliferation and IFN-gamma production. In this work we describe the identification of the mouse B7-H3 homolog, which is ubiquitously expressed in a variety of tissues. Activated CD4 and CD8 T cells express a putative receptor that can be recognized by soluble mouse B7-H3-Ig molecules. While the mouse B7-H3 gene was found to contain a single copy, we discovered a novel isoform of human B7-H3 (named as B7-H3b hereafter) with four Ig-like domains that results from gene duplication and differential splicing. B7-H3b is the major isoform expressed in several tissues. This structural information suggests a genetic variation of the B7-H3 gene in mammalian species.