Propagation of activity-dependent synaptic depression in simple neural networks
Propagation of activity-dependent synaptic depression in simple neural networks
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作者：
Fitzsimonds, RM;Song, HJ;Poo, MM
从培养的海马神经元的简单网络的三重全细胞记录显示，在突触前神经元的树突上的抑郁症的反向传播的抑郁症的输入突触伴随着在海马神经元突触的长期抑郁症的诱导。抑制也横向传播到突触前神经元的发散输出和突触后神经元的会聚输入。在GABA能突触处，抑制没有向前传播到突触后神经元的输出，也没有伴随长期抑制的突触前传播。因此，活动诱导的突触修饰不限于激活的突触，而是选择性地在整个神经网络中传播。
Triple whole-cell recordings from simple networks of cultured hippocampal neurons show that induction of long-term depression at glutamatergic synapses is accompanied by a back propagation of depression to input synapses on the dendrite of the presynaptic neuron. The depression also propagates laterally to divergent outputs of the presynaptic neuron and to convergent inputs on the postsynaptic neuron. There is no forward propagation of depression to the output of the postsynaptic neuron and no presynaptic propagation accompanying long-term depression at GABAergic synapses. Activity-induced synaptic modification is therefore not restricted to the activated synapse, but selectively propagates throughout the neural network.