Noninvasive imaging of bone microarchitecture.

Noninvasive imaging of bone microarchitecture.
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DOI:
10.1111/j.1749-6632.2011.06282.x
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发表时间:
2011-12
影响因子:
5.2
通讯作者:
Majumdar S
Majumdar S
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Patsch JM;Burghardt AJ;Kazakia G;Majumdar S

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通过高分辨率外周定量计算机断层扫描(HR-pQCT)和高分辨率磁共振成像(HR-MRI)可以对外周隔室特异性骨微结构进行无创定量。除了经典的形态指标之外,这两种技术还为使用有限元 (FE) 分析进行虚拟生物力学测试提供了合适的基础。必须考虑方法限制、形态测量参数定义和运动伪影,以实现成像研究的最佳数据解释。随着体内高分辨率骨成像技术的可用性不断增加,应特别重视质量控制,包括多中心、跨站点验证。重要的是,研究抗骨质疏松药物对骨微结构影响的介入研究的结论应该谨慎得出,最好由影像科学家、转化研究人员和临床医生参与。
The noninvasive quantification of peripheral compartment-specific bone microarchitecture is feasible with high-resolution peripheral quantitative computed tomography (HR-pQCT) and high-resolution magnetic resonance imaging (HR-MRI). In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. Methodical limitations, morphometric parameter definition, and motion artifacts have to be considered to achieve optimal data interpretation from imaging studies. With increasing availability of in vivo high-resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross-site validations. Importantly, conclusions from interventional studies investigating the effects of antiosteoporotic drugs on bone microarchitecture should be drawn with care, ideally involving imaging scientists, translational researchers, and clinicians.
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