Influence of the renal artery ostium flow diverter on hemodynamics and atherogenesis.
Influence of the renal artery ostium flow diverter on hemodynamics and atherogenesis.
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DOI：
10.1016/j.jbiomech.2014.03.006
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发表时间：
2014-05-07
影响因子：
2.4
通讯作者：
Rossmann, Jenn Stroud
中科院分区：
文献类型：
--
作者：
Albert, Scott;Balaban, Robert S.;Neufeld, Edward B.;Rossmann, Jenn Stroud
The structure and function of the renal artery ostium flow diverter on the caudal side of the renal branch point were previously reported; in this study, we further evaluate the diverter’s possible functions. The protrusion of this structure into the abdominal aorta suggests that the diverter may preferentially direct blood flow to the renal arteries, and that it may also influence flow patterns and recirculation known to be involved in atherogenesis. Three-dimensional computational fluid dynamics (CFD) simulations of steady and pulsatile blood flow are performed to investigate the influence of diverter size and position, and vascular geometry, on the flow patterns and fluid mechanical forces in the neighborhood of the diverter. CFD results show that the flow diverter does affect the blood distribution: depending on the diverter’s position, the flow to the renal arteries may be increased or reduced. Calculated results also demonstrate the diverter’s effect on the Wall Shear Stress (WSS) distribution, and suggest that the diverter contributes to an atherogenic environment in the abdominal aorta, while being atheroprotective in the renal arteries themselves. These results support previous clinical findings, and suggest directions for further clinical study. The results of this work have direct implications in understanding the physiological significance of the diverter, and its potential role in the pathophysiological development of atherosclerosis.
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影响因子：
3.8
作者：
Taylor, CA;Hughes, TJR;Zarins, CK
通讯作者：
Zarins, CK
影响因子：
8.7
作者：
Yamamoto, T;Ogasawara, Y;Kajiya, F
通讯作者：
Kajiya, F
影响因子：
37.8
作者：
Kwon, Gina P.;Schroeder, Jamie L.;Balaban, Robert S.
通讯作者：
Balaban, Robert S.
DOI：
10.1115/1.2895740
发表时间：
1994-08-01
影响因子：
1.7
作者：
MOORE, JE;KU, DN
通讯作者：
KU, DN
影响因子：
5.3
作者：
IVEY, J;ROACH, MR;KRATKY, RG
通讯作者：
KRATKY, RG