In vitro and in vivo evaluation of an in situ gel forming system for the delivery of PEGylated octreotide
In vitro and in vivo evaluation of an in situ gel forming system for the delivery of PEGylated octreotide
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DOI：
10.1016/j.ejps.2012.09.017
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发表时间：
2013-01-23
影响因子：
4.6
通讯作者：
Dinarvand, Rassoul
中科院分区：
文献类型：
--
作者：
Jabarian, Laleh Erfani;Rouini, Mohammad Reza;Dinarvand, Rassoul
本研究的目的是使用基于泊洛沙姆的原位凝胶形成聚合物开发聚乙二醇化奥曲肽的受控递送系统。与原奥曲肽相比，聚乙二醇化奥曲肽保留了其完整的生物活性和更高的血清半衰期。设计的药物输送系统含有低浓度的泊洛沙姆 407 (P407) (
The objective of this study was to develop a controlled delivery system for PEGylated octreotide using a Poloxamer based in situ gel forming polymer. PEGylated octreotide kept its full biological activity and higher serum half-life compared to the original octreotide. The designed drug delivery system contained low concentration of Poloxamer 407 (P407) (