Lifestyle Intervention in Men with Advanced Prostate Cancer Receiving Androgen Suppression Therapy: A Feasibility Study
Lifestyle Intervention in Men with Advanced Prostate Cancer Receiving Androgen Suppression Therapy: A Feasibility Study
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DOI：
10.1158/1055-9965.epi-10-1143
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发表时间：
2011-04-01
影响因子：
3.8
通讯作者：
Saxton, John M.
中科院分区：
文献类型：
--
作者：
Bourke, Liam;Doll, Helen;Saxton, John M.
背景资料：健康的生活方式行为可能在改善前列腺癌男性雄激素抑制治疗（AST）的某些不良反应方面发挥作用。本研究的主要目的是评估一个锥形监督运动计划的可行性与饮食建议相结合的男性与晚期前列腺癌接受AST.Methods：晚期前列腺癌患者接受AST至少6个月随机分为12周的生活方式计划，包括有氧运动和阻力运动，加上饮食建议（n = 25），或标准护理（n = 25）。在基线、干预后和6个月时评估运动行为、膳食常量营养素摄入、生活质量、疲劳、功能健康和与疾病进展相关的生物标志物。生活方式组在运动行为方面有所改善（P < 0.001）、膳食脂肪摄入量（P <0.001）、总能量摄入量（P = 0.005）、疲劳（P = 0.002）、有氧运动耐量（P < 0.001）和肌肉力量（P = 0.033）。虽然在6个月时观察到高损耗率（44%），但关键健康结局的改善持续存在。未观察到对临床前列腺癌疾病标志物的影响。结论：初步证据表明，务实的生活方式干预有可能改善接受AST治疗的晚期前列腺癌男性的运动和饮食行为，以及其他重要的健康结果。影响：这项研究首次表明，务实的生活方式干预是可行的，并可能对健康行为和其他关键结果产生积极影响。在接受AST治疗的晚期前列腺癌男性中。癌症流行病学生物标志物Prev; 20（4）; 647-57。(C)2011年AACR。
Background: Healthy lifestyle behaviors could have a role in ameliorating some of the adverse effects of androgen suppression therapy (AST) in men with prostate cancer. The primary aim of this study was to assess the feasibility of a tapered supervised exercise program in combination with dietary advice in men with advanced prostate cancer receiving AST.Methods: Advanced prostate cancer patients receiving AST for a minimum of 6 months were randomized to a 12-week lifestyle program comprising aerobic and resistance exercise, plus dietary advice (n = 25), or standard care (n = 25). Exercise behavior, dietary macronutrient intake, quality of life, fatigue, functional fitness, and biomarkers associated with disease progression were assessed at baseline, after the intervention, and at 6 months.Results: The lifestyle group showed improvements in exercise behavior (P < 0.001), dietary fat intake (P 0.001), total energy intake (P = 0.005), fatigue (P = 0.002), aerobic exercise tolerance (P < 0.001), and muscle strength (P = 0.033) compared with standard care controls. Although a high rate of attrition (44%) was observed at 6 months, the improvements in key health outcomes were sustained. No effects on clinical prostate cancer disease markers were observed.Conclusions: This preliminary evidence suggests that pragmatic lifestyle interventions have potential to evoke improvements in exercise and dietary behavior, in addition to other important health outcomes in men with advanced prostate cancer receiving AST.Impact: This study shows for the first time that pragmatic lifestyle interventions are feasible and could have a positive impact on health behaviors and other key outcomes in men with advanced prostate cancer receiving AST. Cancer Epidemiol Biomarkers Prev; 20(4); 647-57. (C) 2011 AACR.