Studies on the biological activities of islandic acid and related compounds.
Studies on the biological activities of islandic acid and related compounds.
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岛酸及相关化合物的生物活性研究。
DOI：
10.1248/cpb.32.1583
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发表时间：
1984
影响因子：
1.7
通讯作者：
H. Hirokawa
中科院分区：
文献类型：
--
作者：
Y. Fujimoto;T. Kihara;K. Isono;H. Tsunoda;T. Tatsuno;K. Matsumoto;H. Hirokawa
本文研究了香岛酸-I（1）及其有关化合物对Yosida肉瘤细胞生长和芽孢杆菌噬菌体M2-DNA转染的影响。化合物1在100μg/ml时抑制吉田肉瘤细胞的生长，而其甲酯（2）的效力是其100倍。Islandic acid-II甲酯（4）和2在33和66μg/ml时分别对芽孢杆菌噬菌体M2-DNA的转染产生83%和97%的抑制。具有与1的侧链相同构型的（2 Z，4 E）-己二烯酸甲酯（5）也在宽浓度范围内抑制M2-DNA的转染，但即使在100μg/ml下也不显示对组织培养中的吉田肉瘤细胞的细胞毒性。
The effects of islandic acid-I (1) and related compounds on the growth of Yosida sarcoma cells and on the transfection of Bacillus phage M2-DNA have been investigated. Compound 1 inhibited the growth of Yoshida sarcoma cells at 100μg/ml, while its methyl ester (2) was 100 times more potent. Islandic acid-II methyl ester (4) and 2 produced 83 and 97% inhibition of the transfection of Bacillus phage M2-DNA at 33 and 66μg/ml, respectively. Methyl (2Z, 4E)-hexadienoate (5), having the same configuration as the side chain of 1, also inhibited the transfection of M2-DNA over a wide concentration range, but did not show cytotoxicity against Yoshida sarcoma cells in tissue culture even at 100μg/ml.