Neutropenia and neutrophil-to-lymphocyte ratio in a healthy Korean population: race and sex should be considered
Neutropenia and neutrophil-to-lymphocyte ratio in a healthy Korean population: race and sex should be considered
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DOI：
10.1111/ijlh.12489
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发表时间：
2016-06-01
影响因子：
3
通讯作者：
Kim, H. R.
中科院分区：
文献类型：
--
作者：
Kweon, O. J.;Lee, M. -K.;Kim, H. R.
我们根据性别和年龄评估了韩国健康人群中无症状中性粒细胞减少症的患病率和严重程度。我们探讨了正常的嗜中性粒细胞-淋巴细胞比率（NLR）和血小板-淋巴细胞比率（PLR）在一个无症状的韩国人口和这些比率与生物标志物相关的炎症，类风湿性疾病，和葡萄糖metabolic.MethodsWe分析了83 740例受试者谁参加了常规的健康检查程序的全血细胞计数。NLR和PLR进行了比较，年龄，类风湿因子，C-反应蛋白（CRP），红细胞沉降率，血红蛋白A1 C，和空腹血糖level.ResultsOf整个研究人群中，7.48%表现出中性粒细胞减少症，8.61%的女性和6.69%的男性。中性粒细胞减少症女性较男性严重（P < 0.01）。中位NLR和PLR值分别为1.53和121.07。NLR与年龄呈负相关，但性别间无差异。CRP，红细胞沉降率，空腹血糖水平与NLR.ConclusionOur数据表明，中性粒细胞绝对计数的正常范围应调整和中性粒细胞减少症的截止值应重新建立根据性别和种族。疾病评估的NLR和PLR截止值应根据人种和年龄分别确定。
IntroductionWe evaluated the prevalence and severity of asymptomatic neutropenia in a healthy Korean population according to sex and age. We explored normal neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in an asymptomatic Korean population and the association of these ratios with biomarkers related to inflammation, rheumatoid disease, and glucose metabolism.MethodsWe analyzed complete blood cell counts in 83 740 subjects who participated in a routine health check-up program. NLR and PLR were compared to age, rheumatoid factor, C-reactive protein (CRP), erythrocyte sedimentation rate, hemoglobin A1c, and fasting glucose levels.ResultsOf the entire study population, 7.48% exhibited neutropenia; 8.61% of females and 6.69% of males. The neutropenia was more severe in females compared to males (P < 0.01). Median NLR and PLR values were 1.53 and 121.07, respectively. An inverse relationship was observed between NLR and age, but no differences were seen between sexes. CRP, erythrocyte sedimentation rate, and fasting glucose level were significantly correlated with NLR.ConclusionOur data indicate that the normal range of absolute neutrophil counts should be adjusted and cutoff values for neutropenia should be re-established according to sex and race. NLR and PLR cutoff values for disease evaluation should be established separately according to race and age.