C-TYPE VIRUS ASSOCIATED WITH GIBBON LYMPHOSARCOMA
C-TYPE VIRUS ASSOCIATED WITH GIBBON LYMPHOSARCOMA
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DOI：
10.1038/newbio235170a0
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
GILDEN, RV
中科院分区：
文献类型：
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作者：
KAWAKAMI, TG;DUNGWORTH, DL;GILDEN, RV
C 型病毒已被确定为鼠类和猫科动物白血病的致病因子，并已得到表征1,2。 C 型病毒也可能与非人类灵长类动物的纤维肉瘤有关3-6。为了确定具有相同特征的病毒是否与猿猴物种中的其他肿瘤相关，我们在白血病病例中寻找 C 型病毒。加利福尼亚大学旧金山医学中心的 Malcolm Jones 博士向比较肿瘤学实验室提供了一只患有播散性肿瘤（后来被证实为淋巴肉瘤）的长臂猿（Hylobates lar）。主要受累部位（淋巴结、肝脏和骨髓）广泛存在大量肿瘤细胞，其中主要是幼淋巴细胞形式。电子显微镜显示C型颗粒与体外淋巴结、肝脏、脾脏和骨髓切片中观察到的颗粒相同。
C-TYPE viruses have been established as the causal agents of leukaemia in murine and feline species and have been characterized1,2. C-type virus is also probably associated with fibrosarcoma in non-human primates3–6. To determine whether viruses with identical characteristics are associated with other neoplasms in simian species, we looked for C-type viruses in cases of leukaemia. A gibbon (Hylobates lar) with a disseminated tumour (later confirmed as lymphosarcoma) was made available to the Comparative Oncology Laboratory by Dr Malcolm Jones of the University of California, San Francisco Medical Center. The principal sites of involvement (lymph node, liver and bone marrow) were extensively overrun with massive neoplastic cells, which were predominantly prolymphocytic forms. Electron microscopy revealed C-type particles identical to those observedin vitroin sections from lymph nodes, liver, spleen and bone marrow.