ZINC, COPPER AND MAGNESIUM CONCENTRATION IN SERUM AND CSF OF PATIENTS WITH NEUROLOGICAL DISORDERS
ZINC, COPPER AND MAGNESIUM CONCENTRATION IN SERUM AND CSF OF PATIENTS WITH NEUROLOGICAL DISORDERS
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DOI：
10.1111/j.1600-0404.1989.tb03803.x
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发表时间：
1989-05-01
影响因子：
3.5
通讯作者：
PAPAGEORGIOU, C
中科院分区：
文献类型：
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作者：
KAPAKI, E;SEGDITSA, J;PAPAGEORGIOU, C
本文用原子吸收分光光度法测定了74例神经系统疾病患者和28例正常人脑脊液（CSF）和血清中锌（Zn）、铜（Cu）、镁（Mg）的含量。周围神经系统疾病组脑脊液锌含量明显升高（P < 0.01），不同神经系统综合征患者脑脊液蛋白含量明显升高（P < 0.001）。脑脊液蛋白增高者脑脊液及血清铜水平增高（P < 0.05）。这可能是由于受损的血脑屏障（BBB）允许微量元素Zn、Cu和Mg进入蛛网膜下腔。多发性硬化（MS）组血清铜水平明显降低（P < 0.01）。调查结果与以前的来文相关。
Zinc (Zn), copper (Cu) and magnesium (Mg) concentrations in cerebrospinal fluid (CSF) and serum were determined with atomic absorption spectrophotometry in 74 patients suffering from various neurological diseases, and in 28 healthy controls. Increased CSF zinc levels were found in the group of peripheral nervous system disease (P < 0.01) and in the cases of different neurological syndromes with increased CSF protein concentration (P < 0.001). Increased CSF and serum copper levels were found in the cases with increased CSF protein levels (P < 0.05). It is probable that the damaged blood-brain-barrier (BBB) permits the passage of the trace elements Zn, Cu and of Mg into the subarachnoid space. Decreaed serum Cu levels (P < 0.01) were found in the group of multiple sclerosis (MS). The findings are correlated to those previous communications.