The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery
The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery
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DOI：
10.3109/02713683.2015.1122813
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发表时间：
2016-10-01
影响因子：
2
通讯作者：
Chung, Sung Kun
中科院分区：
文献类型：
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作者：
Baek, Jiwon;Doh, Sang Hee;Chung, Sung Kun
目的：目的：评价3%地夸磷索四钠滴眼液治疗白内障术后干眼症的疗效。患者被随机分配为一只眼睛接受3.0%地夸磷索四氢呋喃滴眼液，另一只眼睛接受0.9%生理盐水，每天4次，持续8周。在术后1、5和9周使用Schirmer 1试验（SIT）、泪膜破裂时间（TBUT）和荧光素角膜染色测量干眼严重程度。使用傅立叶域光学相干断层扫描和症状问卷评分测量泪半月板高度（TMH）、泪半月板深度（TMD）和泪半月板面积（TMA）。术后8周，3.0%地夸磷索治疗眼的TBUT和角膜染色显著改善（p <0.01，p < 0.01），并优于生理盐水处理眼（p <0.01，p < 0.01）。SIT未改善（p = 0.26）。TMH、TMD和TMA在第4周和第8周没有改善。结论：3.0%地夸磷索治疗可改善白内障术后泪膜稳定性和干眼症的主观症状。由于地夸磷索治疗导致的粘蛋白产生增加可能导致这些结果。
Purpose: To evaluate the effectiveness of 3% diquafosol tetrasodium for treating dry eye after cataract surgery.Methods: Among patients who underwent bilateral cataract surgery, 34, who met the diagnostic criteria for dry eye syndrome 1 week postoperatively, were enrolled. Patients were randomly assigned to receive 3.0% diquafosol tetrasodium ophthalmic solution in one eye and 0.9% saline in the other eye four times daily for 8 weeks. Dry eye severity was measured at 1, 5, and 9 postoperative weeks using the Schirmer 1 test (SIT), tear film breakup time (TBUT), and fluorescein corneal staining. tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) measured using Fourier-domain optical coherence tomography and symptom questionnaire scores.Results: TBUT and corneal staining significantly improved 8 weeks postoperatively in eyes treated with 3.0% diquafosol tetrasodium (p < 0.01, p < 0.01) and were better than normal saline-treated eyes (p < 0.01, p < 0.01). SIT did not improve (p = 0.26). TMH, TMD, and TMA did not improve at 4 and 8 weeks. All symptom questionnaire scores improved in eyes treated with 3.0% diquafosol tetrasodium (all p < 0.01).Conclusion: The 3.0% diquafosol tetrasodium treatment improved tear film stability and subjective symptoms of dry eye after cataract surgery. Increased mucin production as a result of diquafosol treatment may have caused these results.