Serum ferritin and risk of the metabolic syndrome in U.S adults
Serum ferritin and risk of the metabolic syndrome in U.S adults
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DOI：
10.2337/diacare.27.10.2422
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发表时间：
2004-10-01
期刊：
影响因子：
16.2
通讯作者：
Guallar, E
中科院分区：
文献类型：
--
作者：
Jehn, M;Clark, JM;Guallar, E
目的：研究铁储备、代谢综合征和胰岛素抵抗之间的关系。研究设计和方法：我们对参加第三次全国健康和营养检查调查的6044名20岁至20岁的成年人进行了横断面研究。代谢综合征被定义为至少存在以下三项：血压升高、低HDL胆固醇、血清甘油三酯升高、血糖升高和腹部肥胖。使用稳态模型评估（用于胰岛素抵抗）、空腹胰岛素和甘油三酯-高密度脂蛋白胆固醇比率来估计胰岛素抵抗。结果：在排除可能患有血色素沉着症的个体后，绝经前女性、绝经后女性和男性的平均血清铁蛋白值分别为33.6、93.4和139.9马克杯/升。代谢综合征在血清铁蛋白水平最高的绝经前妇女（14.9比6.4%,P = 0.002）、绝经后妇女（47.5比28.2%,P < 0.001）和男性（27.3比13.8%,P < 0.001）中更为常见。胰岛素抵抗在男性和绝经后女性血清铁蛋白的四分位数中也有所增加，并且在调整年龄、种族/民族、c反应蛋白、吸烟、饮酒和BMI后仍持续存在。结论：铁储备升高与代谢综合征患病率和胰岛素抵抗呈正相关。
OBJECTIVE - We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance.RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio.RESULTS - After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 mug/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI.CONCLUSIONS - Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.