Abscopal effect in recurrent colorectal cancer treated with carbon-ion radiation therapy: 2 case reports.
Abscopal effect in recurrent colorectal cancer treated with carbon-ion radiation therapy: 2 case reports.
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DOI：
10.1016/j.adro.2017.06.001
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发表时间：
2017-07
影响因子：
2.3
通讯作者：
Yamada S
中科院分区：
文献类型：
--
作者：
Ebner DK;Kamada T;Yamada S
非局域效应包括局部照射后远处未受照射的疾病的缩小和/或缓解。1这种情况很少见，机制上仍在研究中，尽管最近的病例报告显示，随着免疫调节剂的使用，如CTLA-4抑制剂ipilimumab的使用，这种影响的发生率增加。2、3、4、5、6、7虽然研究主要集中在常规光子照射的使用上，但异常效应似乎是对放射治疗的反应，并且是由免疫系统调节的。粒子照射提供了独特的剂量分布益处，将剂量集中在目标组织中，同时以理论上优于光子的方式节省健康组织。9同时，重离子辐射，例如与碳离子的辐射，由于在每个粒子的基础上提供了更好的线性能量转移，因此提供了额外的生物效应。碳离子放射治疗(CIRT)已成功地应用于复发性直肠癌的治疗。11.
The abscopal effect involves shrinkage and/or remission of distant, unirradiated disease following local irradiation. 1 It is rare and mechanistically remains under study, although recent case reports have seen incidence of the effect increasing with administration of immunomodulatory agents, such as the CTLA-4 inhibitor ipilimumab. 2, 3, 4, 5, 6, 7 The abscopal effect appears to occur in response to radiation therapy and is immune system mediated, 8 although research has predominantly focused on the use of conventional photon irradiation. Particle irradiation offers unique dose distributive benefits, concentrating dose in target tissue while sparing healthy tissue in a manner theoretically superior to photon. 9 Meanwhile, heavy-ion irradiation, such as with carbon ions, offers additional biological effects owing to a superior linear energy transfer delivered on a per-particle basis. 10 Carbon-ion radiation therapy (CIRT) has been used successfully in the treatment of recurrent rectal cancer. 11