Interactions between nonionic Triton X surfactants and cholesterol-containing phosphatidylcholine liposomes
Interactions between nonionic Triton X surfactants and cholesterol-containing phosphatidylcholine liposomes
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非离子型 Triton X 表面活性剂与含胆固醇的磷脂酰胆碱脂质体之间的相互作用
DOI：
10.1016/j.jcis.2006.06.028
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发表时间：
2006-10-01
影响因子：
9.9
通讯作者：
Yang, Yu-Shiue
中科院分区：
文献类型：
--
作者：
Chern, Chorng-Shyan;Chiu, Hsin-Cheng;Yang, Yu-Shiue
通过增溶动力学实验研究了Triton X表面活性剂聚乙二醇链长对其与含胆固醇的磷脂酰胆碱囊泡相互作用的影响。使用经验脂质体稳定性比率来描述囊泡溶解过程。Triton X表面活性剂增溶囊泡的有效性随着表面活性剂聚乙二醇链长的增加而降低。研究还表明，含有最大乙二醇单元数的插层表面活性剂分子的囊泡表现出非常延迟的增溶行为。基于热力学方法的独立实验为从增溶动力学实验获得的结论提供了支持证据。(c)2006年爱思唯尔公司All rights reserved.
Solubilization kinetics experiments were developed to study the effects of the polyethylene glycol chain length of Triton X surfactants on their interactions with the cholesterol-containing phosphatidylcholine vesicles. An empirical liposome stability ratio was used to describe the vesicle solubilization process. The effectiveness of Triton X surfactants in solubilizing vesicles decreases with increasing polyethylene glycol chain length of surfactants. It was also shown that vesicles containing the intercalated surfactant molecules with the largest number of ethylene glycol units per molecule exhibited the exceedingly retarded solubilization behavior. Independent experiments based on a thermodynamic approach provide supporting evidence for the conclusions obtained from solubilization kinetics experiments. (c) 2006 Elsevier Inc. All rights reserved.