Misonidazole enhancement of radiation-induced growth delay in rat rhabdomyosarcoma tumours exposed to accelerated carbon and neon ions.
Misonidazole enhancement of radiation-induced growth delay in rat rhabdomyosarcoma tumours exposed to accelerated carbon and neon ions.
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米索硝唑可增强暴露于加速碳离子和氖离子的大鼠横纹肌肉瘤肿瘤的辐射诱导生长延迟。
DOI：
10.1080/09553008114551001
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Lyman,JT
中科院分区：
文献类型：
--
作者：
Tenforde,TS;Curtis,SB;Tenforde,SD;Parr,SS;Crabtree,KE;Flynn,MJ;Howard,J;Lyman,JT
对一种大鼠横纹肌肉瘤的反应是通过测量低氧细胞增敏剂米索硝唑与单次和分次剂量的X射线以及带电粒子照射所引起的辐射诱导的生长延迟来评估的。单次注射咪唑(500 mg/kg)后，增强倍数为1·8~2·1。225KV X光片。在4 cm的扩展峰电离区，单次给药加碳离子或霓离子照射，增强比为1·2~1·3。每天分4次进行X射线照射，增强比降至1·2~1·5。然而，使用碳离子或霓离子辐射与咪唑联合使用的4次照射计划给出的增强比为1·1~1·3，与使用增敏剂和带电粒子辐射的单剂量计划得到的值相似。
The response of a rat rhabdomyosarcoma tumour was assessed by measurements of radiation-induced growth delay resulting from administration of the hypoxic cell sensitizer misonidazole in combination with single and fractionated doses of X-rays and charged-particle radiation. Enhancement ratios of 1·8–2·1 were obtained following single doses of misonidazole (500 mg/kg i.p.) and 225 kV X-rays. Single doses of misonidazole with either carbon-ion or neon-ion radiation in the 4 cm extended-peak ionization region led to enhancement ratios of 1·2–1·3. When combined misonidazole (300 mg/kg i.p.) and X-ray treatments were given in four daily fractions, the enhancement ratios decreased to 1·2–1·5. However, a four-fraction schedule using either carbon-ion or neon-ion radiation in combination with misonidazole gave enhancement ratios of 1·1–1·3, which are similar to the values obtained for single-dose schedules with the sensitizer and charged-particle radiation.