Adult Physical Activity and Breast Cancer Risk in Women with a Family History of Breast Cancer.
Adult Physical Activity and Breast Cancer Risk in Women with a Family History of Breast Cancer.
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DOI：
10.1158/1055-9965.epi-18-0674
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Sandler DP
中科院分区：
文献类型：
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作者：
Niehoff NM;Nichols HB;Zhao S;White AJ;Sandler DP
娱乐性体育活动一直与降低乳腺癌风险有关。关于乳腺癌家族史如何影响这种联系，以及这种影响是否会因绝经状态而异，人们知之甚少。Sister的研究是对50884名女性的队列研究，她们的姐姐患有乳腺癌，但自己以前没有乳腺癌史。妇女报告了她们在过去12个月中参加的所有娱乐运动/锻炼活动。每周体力活动小时数和每周运动小时数被认为与乳腺癌风险有关。用COX回归计算危险比(HR)和95%可信区间(CI)。家族史的程度，作为一个修饰符，通过结合家庭结构特征的贝叶斯评分来表征。平均随访8.4年，确诊3023例。每周较高的体力活动时间(HR≥7vs1=0.77；95%CI：0.66-0.90)和每周运动时间(HRquartile4vs1=0.75；95%CI：0.67-0.85)与绝经后乳腺癌风险降低相关。每周工作时间和每周工作时间与绝经前乳腺癌风险增加有关(每周工作时间HRquartile4vs1=1.25；95%CI：0.98-1.60)。关联性并不随家族史的程度而变化。然而，绝经前女性的风险增加可能仅限于有较强家族史的女性。在有乳腺癌家族史的女性中，体力活动与绝经后乳腺癌风险的降低有关，但与绝经前的乳腺癌风险无关，而且不受家族史程度的影响。这是第一项在有乳腺癌家族史的人群中研究体力活动与乳腺癌风险之间关系的研究。
Recreational physical activity has been consistently associated with reduced breast cancer risk. Less is known about how family history of breast cancer impacts the association, and whether it varies by menopausal status. The Sister Study is a cohort of 50,884 women who had a sister with breast cancer, but no prior breast cancer themselves. Women reported all recreational sport/exercise activities they participated in over the past 12 months. Hours/week and MET-hours/week of physical activity were considered in association with breast cancer risk. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox regression. Extent of family history, examined as a modifier, was characterized by a Bayesian score incorporating characteristics of the family structure. During follow-up (average 8.4 years), 3,023 cases were diagnosed. Higher hours/week (HR≥7vs<1=0.77; 95%CI: 0.66–0.90) and MET-hours/week (HRquartile4vs1=0.75; 95%CI: 0.67–0.85) of physical activity were associated with reduced postmenopausal breast cancer risk. Hours/week and MET-hours/week were associated with suggestive increased premenopausal breast cancer risk (MET-hours/week HRquartile4vs1=1.25; 95%CI: 0.98–1.60). Associations did not vary with extent of family history. However, the increased risk in premenopausal women may be limited to those with stronger family history. In women with a family history of breast cancer, physical activity was associated with reduced postmenopausal, but not premenopausal, breast cancer risk and was not modified by extent of family history. This was the first study to examine the association between physical activity and breast cancer risk in a large population with a family history of breast cancer.