Respiratory virus infections in adults with hematologic malignancies:: A prospective study
Respiratory virus infections in adults with hematologic malignancies:: A prospective study
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DOI：
10.1086/344899
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发表时间：
2003-01-01
影响因子：
11.8
通讯作者：
Sierra, J
中科院分区：
文献类型：
--
作者：
Martino, R;Rámila, E;Sierra, J
在2年期间，对130例上呼吸道或下呼吸道感染患者的157例连续呼吸道病毒感染进行了呼吸道病毒分析。75例（48%）病例中发现呼吸道病毒，13例病例中发现多种病毒：甲型流感病毒感染56例，呼吸道合胞病毒感染14例，腺病毒感染8例，副流感病毒1型或3型感染8例，肠道病毒感染7例。在多变量分析中，预测上呼吸道感染患者进展为肺炎的唯一变量是呼吸道合胞病毒的存在，而淋巴细胞减少症的趋势不显著。此外，在38例发作期间任何时间发生肺炎的患者中，呼吸道合胞病毒和淋巴细胞减少症都很常见。出于流行病学和治疗的考虑，频繁的呼吸道病毒筛查应纳入血液系统恶性肿瘤患者的常规诊断研究。
During a 2-year period, 157 consecutive episodes of respiratory virus infections that occurred in 130 patients with upper or lower respiratory tract infection were analyzed for respiratory viruses. A respiratory virus was identified in 75 episodes (48%), and several viruses were found in 13 episodes: there were a total of 56 influenza A virus infections, 14 respiratory syncytial virus infections, 8 adenovirus infections, 8 infections with parainfluenza virus types 1 or 3, and 7 enterovirus infections. On multivariate analysis, the only variable that predicted progression to pneumonia in patients with an upper respiratory tract infection was the presence of respiratory syncytial virus, whereas lymphocytopenia had a nonsignificant trend. Also, among the 38 patients who had pneumonia at any time during the episode, both respiratory syncytial virus and lymphocytopenia were commonly found. For both epidemiological and therapeutic considerations, frequent screening for respiratory viruses should be incorporated into the routine diagnostic study of patients with hematologic malignancies.