Burying the dead - The impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
Burying the dead - The impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
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DOI：
10.1378/chest.129.6.1673
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发表时间：
2006-06-01
期刊：
影响因子：
9.6
通讯作者：
Douglas, Ivor S.
中科院分区：
文献类型：
--
作者：
Vandivier, R. William;Henson, Peter M.;Douglas, Ivor S.
细胞凋亡和凋亡细胞的去除（称为细胞凋亡）与正常肺结构的调节密切相关，无论是在发育中还是在成年生物体中。破坏或解偶联这种平衡的过程有可能改变正常的细胞更新，最终导致肺病理和疾病的诱导。凋亡细胞在几种慢性炎性肺病中增加，包括囊性纤维化（CF）、非CF支气管扩张、COPD和哮喘。虽然这很可能是由于细胞凋亡的诱导增强，但越来越多的数据表明，死亡细胞的清除也受到损害。由于肺泡细胞增多症似乎是先天性免疫系统、适应性免疫系统和细胞增殖的关键调节检查点，因此这种高度保守的过程的失败可能通过阻碍炎症的消退和肺泡完整性的维持而促成疾病的发病机制。认识到受损的红细胞增多症是慢性炎症的一个因素，最终可能会引导我们识别新的疾病生物标志物，以及新的治疗方法。
Apoptosis and the removal of apoptotic cells (termed efferocytosis) are tightly coupled with the regulation of normal lung structure, both in the developing and adult organism. Processes that disrupt or uncouple this balance have the potential to alter normal cell turnover, ultimately resulting in the induction of lung pathology and disease. Apoptotic cells are increased in several chronic inflammatory lung diseases, including cystic fibrosis (CF), non-CF bronchiectasis, COPD, and asthma. While this may well be due to the enhanced induction of apoptosis, increasing data suggest that the clearance of dying cells is also impaired. Because efferocytosis appears to be a key regulatory checkpoint for the innate immune system, the adaptive immune system, and cell proliferation, the failure of this highly conserved process may contribute to disease pathogenesis by impeding both the resolution of inflammation and the maintenance of alveolar integrity. The recognition of impaired efferocytosis as a contributor to chronic inflammation may ultimately direct us toward the identification of new disease biomarkers, as well as novel therapeutic approaches.