Effects of a short-term overfeeding with fructose or glucose in healthy young males
Effects of a short-term overfeeding with fructose or glucose in healthy young males
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DOI：
10.1017/s0007114509992819
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发表时间：
2010-04-14
影响因子：
3.6
通讯作者：
Tappy, Luc
中科院分区：
文献类型：
--
作者：
Sock, Emilienne Tudor Ngo;Le, Kim-Anne;Tappy, Luc
在过去的几十年里，简单碳水化合物的消费量显著增加，可能与代谢性疾病的患病率增加有关。果糖摄入量的增加是否与葡萄糖和脂质代谢的失调有关仍然存在争议。因此，我们比较了富含果糖（HFrD）或葡萄糖（HG 1cD）的高热量饮食对健康男性的影响。11名受试者在以下饮食7天后以随机顺序进行研究：（1）体重维持，对照饮食;（2）HFrD（每天3.5 g果糖/kg去脂质量（ffm），+35%能量摄入）;（3）HG 1cD（每天3.5 g葡萄糖/kg ffm，+35%能量摄入）。用6，6-H-2（2）-葡萄糖测定空腹肝葡萄糖输出量（HGO）。肝细胞内脂质（IHCL）和肌细胞内脂质（IMCL）通过H-1磁共振波谱测量。果糖和葡萄糖均增加空腹VLDL-TAG（HFrD：+59%，P
Consumption of simple carbohydrates has markedly increased over the past decades, and may be involved in the increased prevalence in metabolic diseases. Whether an increased intake of fructose is specifically related to a dysregulation of glucose and lipid metabolism remains controversial. We therefore compared the effects of hypercaloric diets enriched with fructose (HFrD) or glucose (HG1cD) in healthy men. Eleven subjects were studied in a randomised order after 7d of the following diets: (1) weight maintenance, control diet; (2) HFrD (3.5g fructose/kg fat-free mass (ffm) per d, +35% energy intake); (3) HG1cD (3.5 g glucose/kg ffm per d, +35% energy intake). Fasting hepatic glucose output (HGO) was measured with 6,6-H-2(2)-glucose. Intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL) were measured by H-1 magnetic resonance spectroscopy. Both fructose and glucose increased fasting VLDL-TAG (HFrD: +59%, P