Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects attachment and infectivity of the organisms in human epithelial and endothelial cells.
Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects attachment and infectivity of the organisms in human epithelial and endothelial cells.
复制标题
N-连接寡糖从衣原体物种表面的裂解影响人体上皮细胞和内皮细胞中生物体的附着和感染性。
DOI：
10.1128/iai.72.11.6699-6701.2004
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Campbell,LeeAnn
中科院分区：
文献类型：
--
作者：
Kuo,Cho-chou;Lee,Amy;Campbell,LeeAnn
先前的研究表明，与衣原体主要外膜蛋白连接的高甘露糖寡糖N抑制了生物体的附着和感染性。本研究表明，用n -聚糖酶裂解多糖可降低衣原体在人上皮细胞和内皮细胞中的附着和感染性。
Previous studies demonstrated that the high-mannose oligosaccharide N linked to theChlamydiamajor outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.