Fungal development of the plant pathogen Ustilago maydis.
Fungal development of the plant pathogen Ustilago maydis.
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DOI：
10.1111/j.1574-6976.2011.00296.x
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发表时间：
2012
影响因子：
11.3
通讯作者：
E. Vollmeister;Kerstin Schipper;S. Baumann;Carl Haag;T. Pohlmann;J. Stock;M. Feldbrügge
中科院分区：
文献类型：
--
作者：
E. Vollmeister;Kerstin Schipper;S. Baumann;Carl Haag;T. Pohlmann;J. Stock;M. Feldbrügge
玉米黑粉菌（Ustilago maydis）为完成其性生活史，必须经历各种形态转变。例如，单倍体细胞对信息素的反应是形成接合管，接合管的尖端融合。由此产生的双核体生长迅速，在顶端迅速扩张，在基极插入收缩隔膜。在这次审查中，我们提出的基本机制，规范这种定义的发展计划的进展。后基因组时代的主要发现如下：（1）内体不仅在受体回收过程中起作用，而且还作为多功能的转运平台;（2）一个新的致病性转录主调节因子是复杂转录网络的一部分;（3）单亲线粒体遗传的决定因素编码在a2交配型位点;（4）线粒体基因组的结构与线粒体基因组的结构密切相关。（4）微管依赖的mRNA运输在决定极性轴方面很重要;（5）基因簇中编码的一系列真菌效应子对植物感染至关重要。重要的是，大多数过程在转录、转录后和翻译后水平上受到严格控制，从而形成复杂的调控网络。这个复杂的系统对于发育阶段的正确顺序的时间至关重要。因此，来自所有调控层的新见解大大提高了我们对真菌发育的理解。
The maize pathogen Ustilago maydis has to undergo various morphological transitions for the completion of its sexual life cycle. For example, haploid cells respond to pheromone by forming conjugation tubes that fuse at their tips. The resulting dikaryon grows filamentously, expanding rapidly at the apex and inserting retraction septa at the basal pole. In this review, we present progress on the underlying mechanisms regulating such defined developmental programmes. The key findings of the postgenomic era are as follows: (1) endosomes function not only during receptor recycling, but also as multifunctional transport platforms; (2) a new transcriptional master regulator for pathogenicity is part of an intricate transcriptional network; (3) determinants for uniparental mitochondrial inheritance are encoded at the a2 mating-type locus; (4) microtubule-dependent mRNA transport is important in determining the axis of polarity; and (5) a battery of fungal effectors encoded in gene clusters is crucial for plant infection. Importantly, most processes are tightly controlled at the transcriptional, post-transcriptional and post-translational levels, resulting in a complex regulatory network. This intricate system is crucial for the timing of the correct order of developmental phases. Thus, new insights from all layers of regulation have substantially advanced our understanding of fungal development.