Low-cost bioanalysis on paper-based and its hybrid microfluidic platforms.
Low-cost bioanalysis on paper-based and its hybrid microfluidic platforms.
复制标题
DOI：
10.1016/j.talanta.2015.04.068
复制
发表时间：
2015-12-01
期刊：
影响因子：
6.1
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Dou M;Sanjay ST;Benhabib M;Xu F;Li X
低成本分析具有广泛的应用范围，从人类健康诊断和食品安全检查到环境分析。因此，低成本的检测方法对财政资源有限的农村地区和发展中国家特别有吸引力。近年来，基于纸张的微流控装置作为一种低成本的平台出现，极大地加快了在低资源环境下的护理点（POC）分析。本文综述了纸基微流控平台低成本生物分析的最新进展，包括全纸基微流控平台和纸基混合微流控平台。本文首先综述了全纸质微流控平台的制备技术及其在人体健康诊断和食品安全分析中的应用。然后我们重点介绍了纸混合微流控平台及其应用，因为混合平台可以从多种器件基材中获益。最后，我们讨论了目前纸张微流控平台用于低成本检测的局限性和前景趋势。
Low-cost assays have broad applications ranging from human health diagnostics and food safety inspection to environmental analysis. Hence, low-cost assays are especially attractive for rural areas and developing countries, where financial resources are limited. Recently, paper-based microfluidic devices have emerged as a low-cost platform which greatly accelerates the point of care (POC) analysis in low-resource settings. This paper reviews recent advances of low-cost bioanalysis on paper-based microfluidic platforms, including fully paper-based and paper hybrid microfluidic platforms. In this review paper, we first summarized the fabrication techniques of fully paper-based microfluidic platforms, followed with their applications in human health diagnostics and food safety analysis. Then we highlighted paper hybrid microfluidic platforms and their applications, because hybrid platforms could draw benefits from multiple device substrates. Finally, we discussed the current limitations and perspective trends of paper-based microfluidic platforms for low-cost assays.