Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients.
Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients.
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DOI：
10.1038/bmt.2015.195
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发表时间：
2016-01
影响因子：
4.8
通讯作者：
Berger NA
中科院分区：
文献类型：
--
作者：
Fiuza-Luces C;Simpson RJ;Ramírez M;Lucia A;Berger NA
异基因造血干细胞移植，以重建造血和免疫状态的患者接受清髓性治疗的血液病，已在最大限度地减少或根除疾病和延长生存期的巨大好处。接受异基因造血干细胞移植（allo-HSCT）的患者患有许多合并症，其中影响生活质量（QoL）和生存率的最重要的合并症是急性（aGVHD）和慢性移植物抗宿主病（cGVHD），由供体淋巴细胞对宿主组织反应和损伤引起。在儿童和成人中，体力活动和锻炼已被清楚地证明可以增强健康，改善健康状况和生活质量，减少疾病进展并延长许多疾病（包括恶性肿瘤）的生存期。在某些情况下，剧烈运动已被证明是等于或更有效的药物治疗。本文综述了cGVHD如何影响患者的身体功能和身体领域的生活质量，以及运动干预的潜在益处，沿着相关研究和评估的建议，这些研究和评估旨在在allo-HSCT后尽快纳入这一策略，理想情况下，在诊断出导致allo-HSCT的疾病后尽快纳入。
Allogeneic Hematopoietic Stem Cell Transplant, to reconstitute hematopoietic and immune status of patients undergoing myeloablative therapy for hematologic disorders, has been of great benefit in minimizing or eradicating disease and extending survival. Patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) are subject to many comorbidities among which the most significant, affecting quality of life (QoL) and survival, are acute (aGVHD) and chronic Graft Versus Host Disease (cGVHD), resulting from donor lymphocytes reacting to and damaging host tissues. Physical activity and exercise have clearly been shown, in both children and adults, to enhance fitness, improve symptomatology and QoL, reduce disease progression and extend survival for many diseases including malignancies. In some cases, vigorous exercise has been shown to be equal to or more effective than pharmacologic therapy. This review addresses how cGVHD affects patients’ physical function and physical domain of QoL, and the potential benefits of exercise interventions along with recommendations for relevant research and evaluation targeted at incorporating this strategy as soon as possible after allo-HSCT and ideally, as soon as possible upon diagnosis of the condition leading to allo-HSCT.