A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.
A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.
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DOI：
10.3389/fneur.2023.1109506
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
支配椭圆囊纹状区I型毛细胞的前庭传入神经元对低频空气传导声（ACS）和骨传导振动（BCV）非常敏感。在这里，我们提出了实验数据和数学模型的椭圆囊力学和前庭复合动作电位的产生（vCAP）在ACS和BCV的临床相关水平。振动的耳锥层相对于感觉上皮使用牛顿的两个自由度的弹簧-质量-阻尼器系统进行模拟，动作电位的时间模拟使用的经验模型，和vCAPs进行模拟卷积响应的敏感神经元的人口与经验的细胞外电压内核。该模型通过与豚鼠体内记录的黄斑振动和vCAP进行比较来验证。短暂刺激诱发短潜伏期vCAP，ACS和BCV的幅度和时间与发束机械剪切速率成比例。对于持续时间<0.8 ms的脉冲BCV刺激，vCAP幅度与颞骨加速度成比例增加，但对于脉冲持续时间>0.9 ms，幅度与颞骨急动度成比例增加。一旦使用ACS和BCV数据进行验证，该模型被应用于预测爆炸引起的毛束剪切，结果预测暴露后立即对毛束造成急性机械损伤。结果表明，开关从线性加速度到线性加加速度，因为足够的刺激产生完全从机械因素控制的感觉毛束偏转的动态。该模型描述了开关的机械振动的自然频率，这是不同的物种之间的形态和机械因素。
Calyx bearing vestibular afferent neurons innervating type I hair cells in the striolar region of the utricle are exquisitely sensitive to auditory-frequency air conducted sound (ACS) and bone conducted vibration (BCV). Here, we present experimental data and a mathematical model of utricular mechanics and vestibular compound action potential generation (vCAP) in response to clinically relevant levels of ACS and BCV. Vibration of the otoconial layer relative to the sensory epithelium was simulated using a Newtonian two-degree-of-freedom spring-mass-damper system, action potential timing was simulated using an empirical model, and vCAPs were simulated by convolving responses of the population of sensitive neurons with an empirical extracellular voltage kernel. The model was validated by comparison to macular vibration and vCAPs recorded in the guinea pig, in vivo. Transient stimuli evoked short-latency vCAPs that scaled in magnitude and timing with hair bundle mechanical shear rate for both ACS and BCV. For pulse BCV stimuli with durations <0.8 ms, the vCAP magnitude increased in proportion to temporal bone acceleration, but for pulse durations >0.9 ms the magnitude increased in proportion to temporal bone jerk. Once validated using ACS and BCV data, the model was applied to predict blast-induced hair bundle shear, with results predicting acute mechanical damage to bundles immediately upon exposure. Results demonstrate the switch from linear acceleration to linear jerk as the adequate stimulus arises entirely from mechanical factors controlling the dynamics of sensory hair bundle deflection. The model describes the switch in terms of the mechanical natural frequencies of vibration, which vary between species based on morphology and mechanical factors.
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DOI：
10.1073/pnas.2207466120
发表时间：
2023-01-10
影响因子：
11.1
作者：
通讯作者：
--
影响因子：
1.7
作者：
Akin, Faith W.;Murnane, Owen D.
通讯作者：
Murnane, Owen D.
影响因子：
2.8
作者：
Curthoys, Ian S.;Vulovic, Vedran;Goonetilleke, Samanthi C.
通讯作者：
Goonetilleke, Samanthi C.
影响因子：
2.5
作者：
Holt, Joseph C.;Chatlani, Shilpa;Goldberg, Jay M.
通讯作者：
Goldberg, Jay M.
影响因子：
2.4
作者：
GOLDSTEIN, MH;KIANG, NYS
通讯作者：
KIANG, NYS