Study of the distribution of antibody-dependent enhancement determinants on dengue 2 isolates using dengue 2-derived monoclonal antibodies.
Study of the distribution of antibody-dependent enhancement determinants on dengue 2 isolates using dengue 2-derived monoclonal antibodies.
复制标题
使用登革热 2 衍生的单克隆抗体研究登革热 2 分离株上抗体依赖性增强决定簇的分布。
DOI：
10.1002/jmv.1890220207
复制
发表时间：
1987
影响因子：
12.7
通讯作者：
Halstead,SB
中科院分区：
文献类型：
--
作者：
Morens,DM;Larsen,LK;Halstead,SB
当使用DEN-2单克隆抗体研究介导抗体依赖性感染增强的决定簇时，在1980年大都市曼谷流行期间从儿童中分离的登革2型（DEN-2）菌株显示具有抗原同质性。所有分离株都具有多种增强因子，但与轻度和重度登革热综合征相关的因子无法区分。登革热疾病严重程度的基础要么比单纯存在或不存在参与增强感染的病毒表位更复杂，要么增强表位在该系统中与针对相同血清型的单克隆抗体未检测到差异。
Dengue 2 (DEN‐2) strains isolated from children during the 1980 metropolitan Bangkok epidemic were shown to possess antigenic homogeneity when studied for determinants mediating antibody‐dependent infection enhancement using DEN‐2 monnoclonal antibodies. All isolates possessed multiple enhancing determinants, but those associated with mild and severe dengue syndromes could not be distinguished. Either the basis of disease severity in dengue is more complex than the mere presence or absence of virus epitopes involved in enhanced infection or enhancing epitopes have differences not detected in this system with monoclonal antibodies raised to the same serotype.