Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-γ
Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-γ
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DOI：
10.1097/00003246-200207000-00015
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发表时间：
2002-07-01
影响因子：
8.8
通讯作者：
Lekka, ME
中科院分区：
文献类型：
--
作者：
Nakos, G;Malamou-Mitsi, VD;Lekka, ME
目的：评价严重创伤患者的局部免疫状态以及干扰素-γ对免疫麻痹患者的影响。患者：52例严重多发伤机械通气患者。设置：14床多价重症监护病房。干预措施：通过检查支气管肺泡灌洗液评价局部免疫状态。随后，患者被分为两组：免疫麻痹（组1）和非免疫麻痹（组2）。免疫麻痹定义为肺泡巨噬细胞人类白细胞抗原-DR表达水平降低，
Objective: To evaluate the local immune status in patients with severe trauma and the influence of interferon-gamma on patients with immunoparalysis.Patients: Fifty-two mechanically ventilated patients with severe multiple trauma.Setting: A 14-bed polyvalent intensive care unit.Interventions: The local immune status was evaluated by examining bronchoalveolar lavage fluid. Subsequently, the patients were divided into two groups: immunoparalyzed (group 1) and nonimmunoparalyzed (group 2). Immunoparalysis was defined as a decreased level of human leukocyte antigen-DR expression of alveolar macrophages in