The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis
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DOI：
10.1016/j.mce.2014.12.011
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发表时间：
2015-06-15
影响因子：
4.1
通讯作者：
Podesta, Ernesto J.
中科院分区：
文献类型：
--
作者：
Castillo, Ana F.;Orlando, Ulises;Podesta, Ernesto J.
类固醇急性调节蛋白（StAR）调节类固醇生成的限速步骤，即胆固醇从线粒体外膜（OMM）传递到线粒体内膜（IMM）。StAR是一种37 kda的蛋白，其n端线粒体靶向序列在线粒体导入过程中被切断，产生30 kda的线粒体内StAR。StAR只作用于OMM，它的活动与它在OMM上停留的时间成正比。然而，尚不清楚StAR留在OMM上的确切方式和分子机制。在这项工作中，我们将讨论线粒体融合和细胞外信号调节激酶1/2 （ERK1/2）对StAR磷酸化的作用，作为调节OMM上StAR保留和活性的机制的一部分。2014爱思唯尔爱尔兰有限公司版权所有。
The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.