Role of thromboxane receptors in the dipsogenic response to central angiotensin II.
Role of thromboxane receptors in the dipsogenic response to central angiotensin II.
复制标题
血栓素受体在中枢血管紧张素 II 的双源反应中的作用。
DOI：
10.1152/ajpregu.00328.2001
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Wilcox,ChristopherS
中科院分区：
文献类型：
--
作者：
Kitiyakara,Chagriya;Welch,WilliamJ;Verbalis,JosephG;Wilcox,ChristopherS
中枢血管紧张素II（ANG II）调节口渴。由于血栓素A2-前列腺素H2（TP）受体在脑中表达，并介导血管紧张素II在血管系统中的一些作用，我们研究了TP受体介导脑室内（icv）注射血管紧张素II的饮水反应的假设。用特异性TP受体拮抗剂伊非曲班（ifetroban，Ifet）预处理可减少50 ng/kg icv ANG II的饮水量（ANG Ⅱ + Veh，7.2 ± 0.7 ml vs. ANG Ⅱ + Ifet，2.8 ± 0.8 ml;n= 5只大鼠; P< 0.001），但对高渗盐水诱导的饮水量没有影响（NaCl + Veh，8.4 ± 1.1 ml vs. NaCl + Ifet，8.9 ± 1.8 ml;n= 5只大鼠;P=不显著）。单独icv给予TP受体激动剂U-46，619 0.6 μg/kg时不会引起饮水，但icv ANG II 15 ng/kg时确实增加了致渴反应（ANG II + Veh，1.1 ± 0.7 vs. ANG II + U-46，619，4.5 ± 0.9 ml;n= 5只大鼠;P< 0.01）。我们的结论是，中央TP受体有助于致渴反应ANG II。
Central angiotensin II (ANG II) regulates thirst. Because thromboxane A2-prostaglandin H2(TP) receptors are expressed in the brain and mediate some of the effects of ANG II in the vasculature, we investigated the hypothesis that TP receptors mediate the drinking response to intracerebroventricular (icv) injections of ANG II. Pretreatment with the specific TP-receptor antagonist ifetroban (Ifet) decreased water intake with 50 ng/kg icv ANG II (ANG II + Veh, 7.2 ± 0.7 ml vs. ANG II + Ifet, 2.8 ± 0.8 ml;n= 5 rats;P< 0.001) but had no effect on water intake induced by hypertonic saline (NaCl + Veh, 8.4 ± 1.1 ml vs. NaCl + Ifet, 8.9 ± 1.8 ml;n= 5 rats;P= not significant). Administration of 0.6 μg/kg icv of the TP-receptor agonist U-46,619 did not induce drinking when given alone but did increase the dipsogenic response to a near-threshold dose of 15 ng/kg icv ANG II (ANG II + Veh, 1.1 ± 0.7 vs. ANG II + U-46,619, 4.5 ± 0.9 ml;n= 5 rats;P< 0.01). We conclude that central TP receptors contribute to the dipsogenic response to ANG II.