Transfer RNA modifications: nature's combinatorial chemistry playground.
Transfer RNA modifications: nature's combinatorial chemistry playground.
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转移RNA修饰：自然的组合化学操场。
DOI：
10.1002/wrna.1144
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发表时间：
2013-01
影响因子：
7.3
通讯作者：
Alfonzo, Juan D.
中科院分区：
文献类型：
--
作者：
Jackman, Jane E.;Alfonzo, Juan D.
在合成之后，tRNA被许多化学修饰点缀，这些修饰可能会对tRNA的结构和功能产生不同的影响。尽管影响tRNA业务端的修饰对细胞活力是可预见的重要，但大多数修饰发挥更微妙的结构作用，可以影响tRNA的稳定性和折叠。目前的趋势是，修饰是协同作用的，并且是在给定tRNA的特定序列的背景下，它们赋予它们不同的效果。最近在修饰领域的发展突出了tRNA修饰的多样性。从这些修饰的组合性质解释先前描述的表型衍生自他们的缺席已经成为一个日益增长的主题。
Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA’s structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their differing effects. Recent developments in the modification field have highlighted the diversity of modifications in tRNA. From these the combinatorial nature of modifications in explaining previously described phenotypes derived from their absence has emerged as a growing theme.