Sodium sensitivity and cardiovascular events in patients with essential hypertension
Sodium sensitivity and cardiovascular events in patients with essential hypertension
复制标题
DOI：
10.1016/s0140-6736(97)05189-1
复制
发表时间：
1997-12-13
期刊：
影响因子：
168.9
通讯作者：
Kimura, G
中科院分区：
文献类型：
--
作者：
Morimoto, A;Uzu, T;Kimura, G
背景：在钠敏感型高血压患者中，肾小球压力升高，微量白蛋白尿是肾小球高血压的标志物，是心血管事件的预测指标。同样，这些患者夜间血压缺乏下降也与心血管事件的风险增加有关。我们假设钠敏感性可能是常见的因素，并对临床上测量过钠敏感性的高血压病患者的心血管事件进行了回顾性研究。方法在对350例高血压患者进行初步调查时，对其钠敏感性进行评估。钠敏感性的定义是低钠或高钠饮食时血压差异10%或更大。按字母顺序，获得201例患者的记录，并对156例无既往疾病的患者进行了随访。在不知道患者的钠敏感状态的情况下，回顾了发生心血管事件或死亡的患者的记录。结果发现，62例患者被认为对钠敏感，94例不对钠敏感，与非钠敏感组相比，左室肥厚的发生率更高(38%比16%；P
Background In patients with sodium-sensitive hypertension, glomerular pressure is increased and microalbuminuria, a marker of glomerular hypertension, is a predictor of cardiovascular events. Similarly, the lack of a nocturnal decrease in blood pressure in these patients is also associated with an increased risk of cardiovascular events. We hypothesised that sodium sensitivity may be the common factor and carried out a retrospective study of cardiovascular events in patients with essential hypertension who had had sodium sensitivity measured in our clinic.Methods Sodium sensitivity was assessed in about 350 patients with essential hypertension during the initial investigation of their disorder. The definition of sodium sensitivity was a 10% or greater difference in blood pressure on low-sodium or high-sodium diets. By alphabetical order, the records of 201 patients were obtained and 156 patients without pre-existing disorders were followed up. The records of patients who had a cardiovascular event or died were reviewed without knowledge of the patient's sodium-sensitivity status.Findings 62 patients were deemed sodium sensitive and 94 non-sodium sensitive, Left-ventricular hypertrophy was found more frequently in the sodium-sensitive group than in the non-sodium-sensitive group (38 vs 16%; p