Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium
Mycotic pseudoaneurysm of a pulmonary artery branch caused by Cladosporium
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DOI：
10.1111/pin.12615
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发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Sugitani, Masahiko
中科院分区：
文献类型：
--
作者：
Sunagawa, Keishin;Uchino, Yoshihito;Sugitani, Masahiko
我们报告一个53岁男性急性骨髓性白血病的病史，谁遭受破裂的右侧肺动脉假性动脉瘤合并肺炎。他接受了右侧下肺叶切除术。切除的肺组织显示肺动脉分支的肌层假性动脉瘤以及丝状真菌感染。假性动脉瘤是由血管壁的所有层破裂引起的。外渗的血液被周围的血管外组织或凝块捕获。枝孢霉是在聚合酶链反应为基础的分析，然后通过福尔马林固定石蜡包埋的肺组织样本的DNA测序检测。虽然以前的病例肺动脉假性动脉瘤引起的真菌感染，例如，念珠菌或曲霉属，据报道，据我们所知，这是第一个涉及枝孢子虫病的病例。
We report the case of a 53-year-old male with a history of acute myelogenous leukemia, who suffered the rupturing of a right-sided pulmonary artery pseudoaneurysm combined with pneumonia. He underwent a right-sided lower lobectomy. The resected lung tissue demonstrated a mycotic pseudoaneurysm of a pulmonary artery branch together with a filamentous fungal infection. Pseudoaneurysms are caused by the breaching of all layers of a blood vessel wall. The extravasated blood is trapped by the surrounding extravascular tissue or clots. Cladosporium was detected during a polymerase chain reaction-based analysis followed by DNA sequencing of formalin-fixed paraffin-embedded lung tissue samples. Although previous cases of pulmonary artery pseudoaneurysms caused by fungal infections, e.g., Candida or Aspergillus sp., have been reported, to the best of our knowledge this is the first case to involve cladosporiosis.