The stroma-a key regulator in prostate function and malignancy.
The stroma-a key regulator in prostate function and malignancy.
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DOI：
10.3390/cancers4020531
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发表时间：
2012-05-29
期刊：
影响因子：
5.2
通讯作者：
Bergh A
中科院分区：
文献类型：
--
作者：
Hägglöf C;Bergh A
前列腺癌是一种非常常见且高度不可预测的癌症。尽管许多前列腺癌生长缓慢并且可能无需治疗，但其他癌症则非常具有侵袭性。此外，目前还没有针对局部或远处转移的前列腺癌患者的治疗方法。因此，非常有必要鉴定新的、改进的前列腺癌预后和诊断生物标志物，并寻找更好的转移性前列腺癌治疗策略。已知上皮和间质之间的相互作用在前列腺发育过程中已经很重要，并且这种相互作用对于原发性肿瘤的发育、进展和转移的生长也至关重要。因此，可以合理地预期，可以在前列腺肿瘤和转移基质中鉴定出未来的生物标志物和治疗靶点，并且应该进一步探讨这种可能性。
Prostate cancer is a very common and highly unpredictable form of cancer. Whereas many prostate cancers are slow growing and could be left without treatment, others are very aggressive. Additionally, today there is no curative treatment for prostate cancer patients with local or distant metastasis. Identification of new, improved prognostic and diagnostic biomarkers for prostate cancer and the finding of better treatment strategies for metastatic prostate cancer is therefore highly warranted. Interactions between epithelium and stroma are known to be important already during prostate development and this interplay is critical also in development, progression of primary tumors and growth of metastases. It is therefore reasonable to expect that future biomarkers and therapeutic targets can be identified in the prostate tumor and metastasis stroma and this possibility should be further explored.