Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study
Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study
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DOI：
10.1159/000450546
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发表时间：
2016-01-01
影响因子：
2.3
通讯作者：
Zamboni, Giovanna
中科院分区：
文献类型：
--
作者：
Griffanti, Ludovica;Wilcock, Gordon K.;Zamboni, Giovanna
背景：我们之前已经表明，阿尔茨海默病（AD）患者额叶静息状态网络中基于fMRI的功能连通性（FC）的增加反映了残留的，可能是代偿性的功能。这表明对症治疗的目标应该是在这些网络中特异性地增强FC。方法：18例疑似AD患者在基线和多奈哌齐治疗12周后进行脑MRI和神经心理学评估。我们测试了治疗后认知表现的变化是否与静息状态网络中FC的变化相关，而静息状态网络已知在AD中发生改变。结果：我们发现眼眶额叶网络中FC的增加与治疗后认知改善相关。在对治疗反应最明显的患者中，FC增加最多。结论：这项“概念验证”研究表明，网络特异性FC的变化可能是阿尔茨海默病药物干预效果的生物标志物。(C) 2016，作者：s . Karger AG，巴塞尔出版
Background: We have previously shown that increased resting-state functional magnetic resonance imaging (fMRI)-based functional connectivity (FC) within the frontal resting-state networks in Alzheimer's disease (AD) patients reflects residual, possibly compensatory, function. This suggests that symptomatic treatments should aim to enhance FC specifically in these networks. Methods: 18 patients with probable AD underwent brain MRI and neuropsy-chological assessment at baseline and after 12 weeks of treatment with donepezil. We tested if changes in cognitive performance after treatment correlated with changes in FC in restingstate networks known to be altered in AD. Results: We found increases in FC in the orbitofrontal network that correlated with cognitive improvement after treatment. The increased FC was greatest in patients who responded most to treatment. Conclusion: This ` proof of concept' study suggests that changes in network-specific FC might be a biomarker of pharmaco-logical intervention efficacy in AD. (C) 2016 The Author(s) Published by S. Karger AG, Basel