Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.
Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.
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含 HMG 盒基因的 Sox 家族的许多成员在发育中的小鼠牙齿中表达。
DOI：
10.1006/geno.1996.0548
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Weiss,KM
中科院分区：
文献类型：
--
作者：
Stock,DW;Buchanan,AV;Zhao,Z;Weiss,KM
我们使用RT-PCR检测的表达在小鼠磨牙和切牙牙胚的19个已知的成员的HMG盒含转录因子的Sox家族的14。这些序列属于Sox家族的所有6个主要细分。在一般情况下，不同的Sox基因的相对转录丰度是相似的臼齿和切牙牙胚之间，虽然3低丰度的成绩单中发现，只有一个单一的牙齿类型。Sox基因在牙齿发育过程中的表达以前没有报道过，需要进一步的实验来确定它们在这一过程中的作用。
We used RT-PCR to detect the expression in mouse molar and incisor tooth germs of 14 of the 19 known members of the Sox family of HMG box-containing transcription factors. These sequences fell into all 6 of the main subdivisions of the Sox family. In general, the relative transcript abundance of the different Sox genes is similar between molar and incisor tooth germs, although 3 low-abundance transcripts were found in only a single tooth type. The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process.