IMMUNOGLOBULIN-G RESPONSE TO SUBGINGIVAL GRAM-NEGATIVE BACTERIA IN HUMAN-SUBJECTS
IMMUNOGLOBULIN-G RESPONSE TO SUBGINGIVAL GRAM-NEGATIVE BACTERIA IN HUMAN-SUBJECTS
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DOI：
10.1128/iai.45.1.47-51.1984
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
TAKAZOE, I
中科院分区：
文献类型：
--
作者：
NAITO, Y;OKUDA, K;TAKAZOE, I
对正常健康成人和牙周炎患者的血清和龈沟液进行龈拟杆菌381、中间芽孢杆菌24、洛氏芽孢杆菌ATCC 15930、核梭杆菌ATCC 25586、腐蚀艾肯氏杆菌1073、放线菌comitans ATCC 29522和嗜糖胞噬菌M-12抗原的IgG抗体检测。采用酶联免疫吸附试验（ELISA）测定对抗原的IgG抗体滴度。牙周炎患者血清和龈沟液中对牙龈白杆菌的抗体水平明显高于健康人。血清龈白杆菌IgG水平与牙周炎的发生呈显著正相关（P < 0.01），但组内存在个体差异。牙周炎患者的核梭菌抗体（P < 0.05）、腐蚀梭菌抗体（P < 0.05）和放线菌抗体（P < 0.05）均略高于正常人。两组间对中间芽孢杆菌、黄芽孢杆菌和嗜碳细胞噬菌的滴度无显著差异。
Serum and gingival crevicular fluid from normal healthy adults and patients with periodontitis were screened for IgG antibodies to antigens from Bacteroides gingivalis 381, B. intermedius 24, B. loescheii ATCC 15930, Fusobacterium nucleatum ATCC 25586 Eikenella corrodens 1073, Actinobacillus actinomycetemcomitans ATCC 29522 and Capnocytophaga sp. strain M-12. IgG antibody titers to the antigens were measured by an enzyme-linked immunosorbent assay [ELISA]. The antibody levels to B. gingivalis in serum and gingival crevicular fluid were significantly higher in the samples from patients with periodontitis than in samples from healthy individuals. Although there were individual differences within patient groups, a positive correlation (P < 0.01) was found between the serum IgG levels to B. gingivalis and the development of periodontitis. The antibodies to F. nucleatum (P < 0.05), E. corrodens (P < 0.05) and A. actinomycetemcomitans were slightly higher in patients with periodontitis than in normal subjects. There were no remarkable differences between the 2 groups in titers to B. intermedius, B. loescheii and Capnocytophaga sp.