Metabolic effects of the consumption of Areca catechu
Metabolic effects of the consumption of Areca catechu
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DOI：
10.1080/13556210120091464
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发表时间：
2002-01-01
影响因子：
3.4
通讯作者：
Mannan, N
中科院分区：
文献类型：
--
作者：
Boucher, BJ;Mannan, N
世界上至少有10%的人口经常咀嚼槟榔（槟榔），无论他们定居在哪里，移民使用者都会进口槟榔，这是第四大最广泛使用的成瘾物质。使用者认为它有舒缓消化和兴奋剂的作用，在社交场合也有重要作用。特定槟榔生物碱作为GABA受体的竞争性抑制剂，在体内具有广泛的作用，包括对大脑、心血管系统、肺、肠道和胰腺的作用。槟榔生物碱的亚硝化衍生物是经证实的致癌物，可在动物的整个上肠和前肠衍生物中诱发肿瘤，也与人类肿瘤风险增加有关。这些亚硝化化合物在CD1小鼠中也会导致糖尿病，导致2型糖尿病伴肥胖。研究发现，中心性肥胖的增加与男性使用槟榔以及炎症和心血管损伤循环标志物的增加有关。长期食用槟榔对人体的影响至少与吸烟的影响一样多样，而且这种习惯会增加不健康的风险。
Betel nut (Areca catechu) is chewed regularly by at least 10% of the world population, imported by immigrant users wherever they settle, and is the fourth most widely used addictive substance. It is thought, by users, to soothe the digestion and to be a stimulant and its use has a major role in social situations. Specific arecal alkaloids act as competitive inhibitors of GABA receptors and have widespread effects in the body, including actions on the brain, cardiovascular system, lungs, gut and pancreas. Nitrosated derivatives of arecal alkaloids, proven carcinogens inducing tumours throughout the upper gut and foregut derivatives in animals, are also associated with increased tumour risks in man. These nitrosated compounds are also diabetogenic in CD1 mice, producing a type 2 diabetes with obesity. Increased central obesity is found in association with betel usage in man as well as increases in circulating markers of inflammatory and cardiovascular damage. The effects of chronic betel usage in man are at least as diverse as those of smoking and the habit increases the risks of ill health.