METABOLIC DYNAMICS IN THE HUMAN RED-CELL .1. A COMPREHENSIVE KINETIC-MODEL
METABOLIC DYNAMICS IN THE HUMAN RED-CELL .1. A COMPREHENSIVE KINETIC-MODEL
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DOI：
10.1016/s0022-5193(89)80233-4
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发表时间：
1989-12-19
影响因子：
2
通讯作者：
PALSSON, BO
中科院分区：
文献类型：
--
作者：
JOSHI, A;PALSSON, BO
在过去的三十年里，对红细胞的实验研究积累了大量关于其酶和代谢产物的生化数据。这项工作的目标是提供一个统一的理论框架，这些数据的整合和一致的解释，通过一个全面的数学代谢模型的红细胞。该模型分为四个部分。在这里，我们描述的一般概念，范围和模型的生物学假设。该模型由基于化学计量和酶动力学的动态质量平衡以及渗透平衡和电神经性的物理化学约束组成。
The experimental investigation of the red cell over the last three decades has accumulated extensive biochemical data on its enzymes and metabolites. The goal of this work is to provide a unified theoretical framework for the integration and consistent interpretation of these data by means of a comprehensive mathematical metabolic model of the red cell. This model is described in four parts. Here, we describe the general conception, scope and the biological assumptions of the model. The model is comprised of dynamic mass balances based on stoichiometry and enzyme kinetics with the imposed physico-chemical constraints of osmotic balance and electroneurality.