Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: A behavioral economic analysis
Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: A behavioral economic analysis
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DOI：
10.1124/jpet.301.3.993
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发表时间：
2002-06-01
影响因子：
3.5
通讯作者：
Carroll, ME
中科院分区：
文献类型：
--
作者：
Cosgrove, KP;Carroll, ME
越来越多的证据表明κ阿片受体激动剂调节可卡因维持的行为，有限的研究结果表明κ阿片受体参与乙醇维持的行为。本研究的目的是研究布马佐辛（一种 κ 阿片类激动剂）对恒河猴（Macaca mulatta）自我施用烟熏可卡因碱和口服乙醇的影响。为了确定布马佐辛的选择性，还检查了布马佐辛预处理对苯环己哌啶（PCP）、糖精和食物的口服自我给药的影响。成年雄性恒河猴接受训练，在日常训练中自行口服乙醇、五氯苯酚、糖精 (n = 8)、食物 (n = 6) 或吸食可卡因碱 (n = 6) 和水。在治疗前 15 分钟注射布马佐辛（0.00032、0.001 和 0.0025 mg/kg i.m.）。预处理前 4 天的稳定行为作为基线。通过改变药物输送成本 (FR) 和测量消耗量（输送量），获得了吸食可卡因碱、乙醇和五氯苯酚的需求曲线（消耗量 x 固定比率；FR）。以非系统性顺序在每个 FR 值处施用布马佐辛 (0.001 mg/kg)。结果表明，布马佐辛剂量依赖性地减少可卡因、乙醇、五氯苯酚和糖精的摄入量。在六只猴子中的五只中，布马佐辛对食物摄入的影响小于其他物质。一般来说，布马佐辛治疗减少了对可卡因、乙醇和五氯苯酚以及其他反应强度指标的需求。这些结果扩展了以下发现：κ 激动剂减少了恒河猴对吸食可卡因碱和口服乙醇、五氯苯酚和糖精的药物和非药物强化剂的自我给药。
There is increasing evidence that kappa-opioid receptor agonists modulate cocaine-maintained behavior, and limited findings implicate the involvement of kappa-opioid receptors in ethanol-maintained behaviors. The purpose of the present study was to investigate the effects of bremazocine, a kappa-opioid agonist, on the self-administration of smoked cocaine base and oral ethanol in rhesus monkeys (Macaca mulatta). To determine the selectivity of bremazocine, the effects of bremazocine pretreatment on the oral self-administration of phencyclidine (PCP), saccharin, and food were also examined. Adult male rhesus monkeys were trained to self-administer oral ethanol, PCP, saccharin (n = 8), food (n = 6), or smoked cocaine base (n = 6) and water during daily sessions. Bremazocine (0.00032-, 0.001-, and 0.0025- mg/kg i.m.) injections were given 15 min before session. The 4 days of stable behavior before pretreatment served as baseline. Demand curves (consumption x fixed ratio; FR) were obtained for smoked cocaine base, ethanol, and PCP by varying the cost (FR) of drug deliveries and measuring consumption (deliveries). Bremazocine (0.001 mg/ kg) was administered at each FR value in nonsystematic order. Results indicate that bremazocine dose dependently reduced cocaine, ethanol, PCP, and saccharin intake. Food intake was affected less by bremazocine than the other substances in five of the six monkeys. Generally, bremazocine treatment reduced the demand for cocaine, ethanol, and PCP as well as other measures of response strength. These results extend the findings that kappa-agonists reduce the self-administration of drug and nondrug reinforcers to smoked cocaine base and oral ethanol, PCP, and saccharin in rhesus monkeys.