Age-Specific Cluster of Cases of Serotype 1 Streptococcus pneumoniae Carriage in Remote Indigenous Communities in Australia
Age-Specific Cluster of Cases of Serotype 1 Streptococcus pneumoniae Carriage in Remote Indigenous Communities in Australia
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DOI：
10.1128/cvi.00283-08
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发表时间：
2009-02-01
影响因子：
--
通讯作者：
Leach, A. J.
中科院分区：
文献类型：
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作者：
Smith-Vaughan, H.;Marsh, R.;Leach, A. J.
2001年开始为澳大利亚土著婴儿接种七价肺炎球菌结合疫苗。肺炎球菌携带监测发现大量替换为非疫苗血清型和血清1型携带群。我们的目的是审查肺炎链球菌血清1型携带和侵袭性肺炎球菌疾病（IPD）的数据，为这一人群和分析血清1型分离株。运输数据收集于1992年至2004年之间，在达尔文地区，在北领地的五个地区之一。2003年和2005年还从北领地的四个地区收集了运输数据。1994年至2007年，北领地报告了26例血清1型IPD病例。44株进行了BOX分型，11株进行了多位点序列分型。在达尔文地区，2002年报告有26名儿童携带血清1型（ST 227），但在后来的监测中没有。在其他两个地区发现了血清1型携带者的零星病例。血清1型与其他肺炎球菌血清型的共定植很常见（34%血清1型阳性拭子）。总之，在澳大利亚北领地土著社区的儿童中，肺炎球菌携带研究检测到间歇性血清1型携带和ST 227群集。在此期间，血清1型IPD没有明显增加。血清1型与其他肺炎球菌血清型的共定植率表明，可能低估了该血清型的携带率。
Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated.