Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid.
Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid.
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化学合成和梯烷磷脂的自组装。
DOI：
10.1021/jacs.6b10706
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发表时间：
2016-12-14
影响因子：
15
通讯作者：
Burns NZ
中科院分区：
文献类型：
--
作者：
Mercer JA;Cohen CM;Shuken SR;Wagner AM;Smith MW;Moss FR 3rd;Smith MD;Vahala R;Gonzalez-Martinez A;Boxer SG;Burns NZ
由厌氧氨氧化细菌产生的梯形脂质构成了生物膜脂质中结构最迷人但研究最少的分子。生产生物的缓慢生长和纯化复杂脂质混合物的固有困难已经阻止了有用量的天然梯烷脂质的分离。我们已经设计了一个高选择性的全合成ladderane脂质尾巴和一个完整的磷脂酰胆碱，使这些分子的化学均匀的样品的生物物理研究。此外，我们报告的第一个证据的绝对配置的天然ladderane。
Ladderane lipids produced by anammox bacteria constitute some of the most structurally fascinating yet poorly studied molecules among biological membrane lipids. Slow growth of the producing organism and the inherent difficulty of purifying complex lipid mixtures have prohibited isolation of useful amounts of natural ladderane lipids. We have devised a highly selective total synthesis of ladderane lipid tails and a full phosphatidylcholine to enable biophysical studies on chemically homogeneous samples of these molecules. Additionally, we report the first proof of absolute configuration of a natural ladderane.