Iron-deficiency anemia as presentation of pouchitis.
Iron-deficiency anemia as presentation of pouchitis.
复制标题
缺铁性贫血表现为储袋炎。
DOI：
10.1097/01.mcg.0000212641.90477.d0
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发表时间：
2007
影响因子：
2.9
通讯作者：
Morales,Lilliana
中科院分区：
文献类型：
--
作者：
Pastrana,RafaelJ;Torres,EstherA;Arroyo,JesusM;Rivera,CynthiaE;Sanchez,CarlosJ;Morales,Lilliana
背景 IPAA 是治疗 UC 的首选手术方法。并发症包括储袋炎（40%）、狭窄（30%）、小肠梗阻（10%）、盆腔败血症（< 5%）以及泌尿和性功能障碍（< 5%）。很少有研究描述 IPAA 后贫血的患病率，但尚未报告结论性的发现。 研究从 UPR 炎症性肠病诊所和胃肠病学研究单位招募接受 IPAA 治疗 UC 的患者。获得了人口统计和医疗数据。使用标准血液学标准诊断贫血。对贫血患者的血清铁、铁蛋白、转铁蛋白、叶酸、维生素 B12、促红细胞生成素、总铁结合力、网织红细胞计数、外周血涂片和骨髓抽吸物进行评估。采用EPI Info 6.4 d版进行数据分析。结果55.5%（10/18）的患者发现缺铁性贫血，77%（14/18）的患者发现储袋炎。 10 名贫血患者全部患有储袋炎，而 8 名不贫血的患者中只有 4 名患有储袋炎。一半贫血患者的储袋炎无症状。结论缺铁性贫血可能是储袋炎的临床表现。血红蛋白水平可被视为 IPAA 患者储袋炎的监测工具。
Background IPAA is the surgical procedure of choice for UC. Complications include pouchitis (40%), strictures (30%), small bowel obstruction (10%), pelvic sepsis (< 5%), and urinary and sexual dysfunctions (< 5%). Few studies have described the prevalence of anemia after IPAA, but no conclusive findings have been reported.Study Patients who had undergone IPAA for UC were recruited from the UPR Inflammatory Bowel Disease Clinic and the Gastroenterology Research Unit. Demographic and medical data were obtained. Anemia was diagnosed using standard hematologic criteria. Serum iron, ferritin, transferrin, folate, vitamin B12, erythropoietin, total iron-binding capacity, reticulocyte count, peripheral smear, and bone marrow aspirate were evaluated in patients with anemia. Data analysis was performed with EPI Info version 6.4 d.Results Iron-deficiency anemia was identified in 55.5%(10/18) of patients and pouchitis was found in 77%(14/18). All 10 patients with anemia had pouchitis, whereas only 4 of the 8 without anemia had pouchitis. In half of the anemic patients, pouchitis was asymptomatic.Conclusions Iron-deficiency anemia may be a clinical presenting sign of pouchitis. Hemoglobin levels may be considered as surveillance tools for pouchitis in patients with IPAA.