Patterns of emergency admission for IBD patients over the last 10 years in Lothian, Scotland: a retrospective prevalent cohort analysis.
Patterns of emergency admission for IBD patients over the last 10 years in Lothian, Scotland: a retrospective prevalent cohort analysis.
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DOI：
10.1111/apt.16867
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发表时间：
2022-07
影响因子：
7.6
通讯作者：
Jones, Gareth-Rhys
中科院分区：
文献类型：
--
作者：
Lyons, Mathew;Derikx, Lauranne A. A. P.;Fulforth, James;McCall, Sophie;Plevris, Nikolas;Jenkinson, Philip W.;Kirkwood, Kathryn;Siakavellas, Spyros;Lucaciu, Laura;Constantine-Cooke, Nathan;Arnott, Ian D.;Henderson, Paul;Russell, Richard K.;Wilson, David C.;Lees, Charlie W.;Jones, Gareth-Rhys
目前尚不清楚炎症性肠病（IBD）的复合患病率如何转化为住院的原因和比率，特别是在生物制剂处方增加的时代。我们旨在分析过去10年中基于人群的IBD队列的这些趋势。洛锡安IBD登记是苏格兰NHS洛锡安IBD患者的完整、经验证、流行数据库。对2010年1月1日至2019年12月31日期间所有IBD患者入院接受二级护理的出院信的ICD-10编码进行了入院原因调查，并与当地/国家死亡和处方药物数据集相关联。在2010年1月1日至2019年12月31日期间，57%（4673/8211）的IBD患者接受二级护理>24小时。在<40岁的患者中，IBD是最常见的入院原因（占入院人数的38%），而感染是>60岁患者中最常见的原因（占入院人数的19%）。3%（243/8211）的IBD患者占研究期间IBD总床日的50%。2010年至2019年，年龄标准化IBD入院率从每10万人口39.4例下降至25.5例，平均每年下降3%（95%CI-4.5%至-2.1%，p < 0.0001）。非IBD住院率总体保持不变（145-137/100，000人群），特别是在同一时期严重（住院）和重度（ITU住院或死亡）感染。尽管复合患病率和生物制品的使用增加，但IBD的入院率正在下降。入院原因随年龄而异，感染是老年患者的主要原因。苏格兰洛锡安地区近10年来IBD患者急诊入院的模式：一项回顾性流行队列分析
It is unclear how the compounding prevalence of inflammatory bowel disease (IBD) has translated into the causes and rates of hospitalisation, particularly in an era of increased biologic prescribing. We aimed to analyse these trends in a population‐based IBD cohort over the last 10 years. The Lothian IBD registry is a complete, validated, prevalent database of IBD patients in NHS Lothian, Scotland. ICD‐10 coding of hospital discharge letters from all IBD patient admissions to secondary care between 1 January 2010 and 31 December 2019 was interrogated for admission cause, with linkage to local/national data sets on death and prescribed drugs. Fifty‐seven per cent (4673/8211) of all IBD patients were admitted to secondary care for >24 h between 1 January 2010 and 31 December 2019. In patients <40 years, IBD was the commonest reason for admission (38% of admissions), whereas infection was the most common cause in those >60 years (19% of admissions). Three per cent (243/8211) of IBD patients accounted for 50% of the total IBD bed‐days over the study period. Age‐standardised IBD admission rates fell from 39.4 to 25.5 admissions per 100,000 population between 2010 and 2019, an average annual percentage reduction of 3% (95% CI −4.5% to −2.1%, p < 0.0001). Non‐IBD admission rates were unchanged overall (145–137 per 100,000 population) and specifically for serious (hospitalisation) and severe (ITU admission or death) infection over the same period. Despite compounding prevalence and increased biologic use, IBD admission rates are falling. The cause of admission varies with age, with infection the predominant cause in older patients. Patterns of emergency admission for IBD patients over the last 10 years in Lothian, Scotland: A retrospective prevalent cohort analysis.
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影响因子：
24.5
作者：
Hovde, Oistein;Kempski-Monstad, Iril;Moum, Bjorn A.
通讯作者：
Moum, Bjorn A.
影响因子：
3.4
作者：
Jenkinson, Philip W.;Plevris, Nikolas;Lees, Charlie W.
通讯作者：
Lees, Charlie W.
影响因子：
29.4
作者：
Coward, Stephanie;Clement, Fiona;Kaplan, Gilaad G.
通讯作者：
Kaplan, Gilaad G.
影响因子：
12.6
作者：
Lichtenstein, GR;Feagan, BG;Sandborn, WJ
通讯作者：
Sandborn, WJ
影响因子：
158.5
作者：
Feagan, B. G.;Sandborn, W. J.;Rutgeerts, P.
通讯作者：
Rutgeerts, P.