Asymmetric mannich reaction of malonates with imines catalyzed by a chiral calcium complex.
Asymmetric mannich reaction of malonates with imines catalyzed by a chiral calcium complex.
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DOI：
10.1021/jo902383b
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
T. Poisson;T. Tsubogo;Y. Yamashita;S. Kobayashi
中科院分区：
文献类型：
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作者：
T. Poisson;T. Tsubogo;Y. Yamashita;S. Kobayashi
研究了手性钙配合物对丙二酸酯与N-叔丁氧羰基亚胺的Mannich反应的影响。以优异的产率（高达95%）和中等至良好的对映选择性（高达77%ee）获得所需的加合物。
A chiral calcium complex was found to be effective for the Mannich reactions of malonates with N-Boc imines. The desired adducts were obtained in excellent yields (up to 95%) with moderate to good enantioselectivities (up to 77% ee).