Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure-Associated Liver Disease in Pediatric Patients
Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure-Associated Liver Disease in Pediatric Patients
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DOI：
10.1177/0148607115625779
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发表时间：
2017-07-01
影响因子：
3.4
通讯作者：
Gondolesi, Gabriel
中科院分区：
文献类型：
--
作者：
Rumbo, Carolina;Ines Martinez, Maria;Gondolesi, Gabriel
背景：肠衰竭相关性肝病（IFALD）是肠移植的常见适应症。肝活检（LBX）是其诊断的金标准测试。识别纤维化进展的非侵入性标志物将具有相当大的临床用途。天冬氨酸转氨酶/血小板比值指数（APRI）与成年慢性肝病患者有良好的相关性；对 IFALD 儿童进行的研究很少。目的：评估 IFALD 儿童队列中的 APRI。材料和方法：对与晚期纤维化相关的患者 1.6 的前瞻性数据库进行回顾性分析。
Background: Intestinal failure-associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) is the gold standard test for its diagnosis. Identifying noninvasive markers of fibrosis progression would be of considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has a good correlation in adult patients with chronic liver disease; few studies have been performed in children with IFALD. Aim: To evaluate APRI in a cohort of children with IFALD. Materials and Methods: Retrospective analysis of a prospective database of patients 1.6 correlates with advanced fibrosis.